To compare the efficacy of preoperative nebulization with magnesium sulfate and normal saline in reducing the incidence of postoperative sorethroat following tracheal intubation in patients receiving general anaesthesia

Effect of Magnesium Sulfate nebulisation on incidence of postoperative sorethroat; A Randomized prospective double blinded study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/09/057713

Enrollment

Registered

2023-09-15

Start date

Unknown

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Magnesium Sulfate: Pre induction nebulization with magnesium sulfate 250 mg in 3ml of normal saline over 15 minutes before intubation. Control Intervention1: Normal Saline: Pre inductio

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I and II Duration of surgery being less than 2 hours

Exclusion criteria

Exclusion criteria: ASA grade III & IV Age 60 years Pregnant patient Refusal of consent for procedure Allergy or hypersensitivity to magnesium drugs Pateints undergoing ENT,dental,neck surgeries Procedures lasting for more than 2 hours Patients having pre-operative sore throat,cough,hoarseness of voice Patients receiving IV/ Nebulisation with steroids Patients having anticipated difficult airway(Mallampati III & IV

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of preoperative nebulization with magnesium sulfate 250mg in 3ml of normal saline versus 3ml of 0.9% normal saline in reducing the incidence of post operative sore throat following tracheal intubation with endotracheal tube in patients receiving general anaesthesia.Timepoint: Before induction. at 0 hour of immediate extubation. at 4th hour post op at 8th hour post op at 12th hour post op at 24th hour post op at 48th hour post op	—

Measure

Time frame

To compare the efficacy of preoperative nebulization with magnesium sulfate 250mg in 3ml of normal saline versus 3ml of 0.9% normal saline in reducing the incidence of post operative sore throat following tracheal intubation with endotracheal tube in patients receiving general anaesthesia.Timepoint: Before induction. at 0 hour of immediate extubation. at 4th hour post op at 8th hour post op at 12th hour post op at 24th hour post op at 48th hour post op

—

Secondary

Measure	Time frame
To assess the reduction in the incidence of cough & hoarseness of voice following nebulization with magnesium sulfate and normal saline in the post operative period.Timepoint: Before induction. at 0 hour of immediate extubation. at 4th hour post op at 8th hour post op at 12th hour post op at 24th hour post op at 48th hour post op	—

Countries

India

Contacts

Public ContactDr Manisha Bhagat

Rajendra Institute of Medical Sciences, Ranchi

dipalishio@gmail.com9620310511

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026