Comparison of the effectiveness of calcium hydroxide, triple antibiotic paste, bromelain extract, and Triticum aestivum (wheat grass) extract as an intracanal medication against Enterococcus faecalis in single-rooted teeth

Comparative evaluation of anti- microbial efficacy of calcium hydroxide, triple antibiotic paste, bromelain extract and Triticum aestivum extract (Wheat grass) as an intracanal medicament against Enterococcus faecalis in single rooted teeth: an in vivo study - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/09/057678

Enrollment

Registered

2023-09-15

Start date

Unknown

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp Health Condition 2: K047- Periapical abscess without sinus

Interventions

Intervention1: Gp 1- CALCIUM HYDROXIDE Gp 2- TRIPLE ANTIBIOTIC PASTE Gp 3- BROMELAIN EXTRACT Gp 4- Triticum aestivum EXTRACT (WHEAT GRASS): Gp 1- CALCIUM HYDROXIDE mixed with propylene glycol Gp 2- T

2.7 gm of powder and 5 drops of liquid (0.2 ml). It will be placed in the root canal as an intracanal medicament for 7 days. Control Intervention1: NIL: NIL Control Intervention2: TRIPLE ANTIBIOTIC P

2.7 gm of powder and 5 drops of liquid (0.2 ml). It will be placed in the root canal as an intracanal medicament for 7 days. Control Intervention3: BROMELAIN EXTRACT: BROMELAIN EXTRACT mixed with prop

2.7 gm of powder and 5 drops of liquid (0.2 ml). It will be placed in the root canal as an intracanal medicament for 7 days. Control Intervention4: Triticum aestivum EXTRACT (WHEAT GRASS): Triticum ae

Eligibility

Inclusion criteria

Inclusion criteria: 1. Single rooted teeth with single canal 2. Teeth with necrotic or infected pulp as diagnosed clinically and radiographically 3. Sufficient coronal structure for adequate isolation 4. Age of patients between 18-55 years 5. Patients with non-contributory medical history

Exclusion criteria

Exclusion criteria: 1. Teeth with external/internal resorption 2. Teeth with Calcified canal 3. Patients who do not consent to participate in the study 4. Teeth with open apices 5. Pregnant females 6. Patients with Systemic Conditions

Design outcomes

Primary

Measure	Time frame
1. To evaluate in-vivo the anti-microbial efficacy of Calcium hydroxide as an intracanal medicament against Enterococcus faecalis in single rooted teeth. 2. To evaluate in-vivo the anti-microbial efficacy of Triple antibiotic paste [Metronidazole 400mg + Ciprofloxacin 500mg + Clindamycin 150mg] as an intracanal medicament against Enterococcus faecalis in single rooted teeth. 3. To evaluate in-vivo the anti-microbial efficacy of Bromelain extract as an intracanal medicament against Enterococcus faecalis in single rooted teeth. 4. To evaluate in-vivo the antimicrobial efficacy of Triticum aestivum extract (Wheat Grass) as an intracanal medicament against Enterococcus faecalis in single rooted teeth.Timepoint: Before treatment, After 7 days of treatment	—

Measure

Time frame

1. To evaluate in-vivo the anti-microbial efficacy of Calcium hydroxide as an intracanal medicament against Enterococcus faecalis in single rooted teeth. 2. To evaluate in-vivo the anti-microbial efficacy of Triple antibiotic paste [Metronidazole 400mg + Ciprofloxacin 500mg + Clindamycin 150mg] as an intracanal medicament against Enterococcus faecalis in single rooted teeth. 3. To evaluate in-vivo the anti-microbial efficacy of Bromelain extract as an intracanal medicament against Enterococcus faecalis in single rooted teeth. 4. To evaluate in-vivo the antimicrobial efficacy of Triticum aestivum extract (Wheat Grass) as an intracanal medicament against Enterococcus faecalis in single rooted teeth.Timepoint: Before treatment, After 7 days of treatment

—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Dakshita Joy Sinha

Inderprastha Dental College & Hospital

dvaghela52@gmail.com9760340728

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026