COMPARATIVE STUDY OF THE EFFICACY AND SAFETY OF 10% RETINOL PEEL AND 70% GLYCOLIC ACID PEEL IN THE TREATMENT OF ACANTHOSIS NIGRICANS

An observational study of the efficacy and safety comparing 10% Retinol peel and 70% Glycolic acid peel in the treatment of Acanthosis Nigricans

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/09/057674

Enrollment

Registered

2023-09-15

Start date

Unknown

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L83- Acanthosis nigricans

Interventions

Intervention1: 10 % RETINOL PEEL: CHEMICAL PEELING IN ACANTHOSIS NIGRICANS DURATION: 2.5 MONTHS Once local application for every 2 weeks Control Intervention1: 70 % GLYCOLIC ACID: CHEMICAL PEELING IN

Eligibility

Inclusion criteria

Inclusion criteria: CLINICALLY DIAGNOSED AND CONSENTING PATIENTS WITH ACANTHOSIS NIGRICANS

Exclusion criteria

Exclusion criteria: 1. Patients with Post inflammatory hyperpigmentation and other facial dermatoses. 2. Pregnant and Lactating women. 3. Patients who are on topicals/systemic retinoids and other de-pigmenting agents. 4. Non-consenting patients. 5. Patients with unrealistic expectations.

Design outcomes

Primary

Measure	Time frame
1. To determine the efficacy and safety of 10% Retinol peel in the treatment of Acanthosis Nigricans. 2. To determine the efficacy and safety of 70% Glycolic acid peel in the treatment of Acanthosis Nigricans. 3. To compare the efficacy and safety of the following two treatment options.Timepoint: 2.5 MONTHS	—

Secondary

Measure	Time frame
1. Acanthosis Nigricans Area and Severity Index (ANASI) 2. Investigator’s Global Evaluation (IGE) scale. 3. Participant’s Global Evaluation (PGE) scale. 4. Cutaneous adverse reactions scale. 5.Dermatoscopic findings.Timepoint: 2.5 MONTHS	—

Countries

India

Contacts

Public ContactCHERUKUPALLI ANANTH

DR. B R AMBEDKAR MEDICAL COLLEGE AND HOSPITAL

drshilpark@gmail.com7483412510

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026