affect of curcumin on oral mucosa evaluated histopathologically in Leukoplakia cases

Evaluation of anti-tumor properties of curcumin in oral Leukoplakia – A Pilot study - Curcumin Leukoplkia

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/09/057594

Enrollment

Registered

2023-09-13

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K132- Leukoplakia and other disturbancesof oral epithelium, including tongue

Interventions

Intervention1: curcumin capsule: 1 capsule 30mg per day for 3 months Intervention2: curcumin capsule commercially available (Approved by Ayush Dr): Curcumin Turmeric Capsules, 30mg will be given to pa

Eligibility

Inclusion criteria

Inclusion criteria: oral leukoplakia

Exclusion criteria

Exclusion criteria: any other white lesion of oral cavity

Design outcomes

Primary

Measure	Time frame
To observe changes in oral mucosa in cases of oral Leukoplakia by performing a biopsy to see histopathological changes after administration of curcumin capsules for 3 monthsTimepoint: To observe changes in oral mucosa in cases of oral Leukoplakia by performing a biopsy to see histopathological changes after administration of curcumin capsules for 3 months	—

Secondary

Measure	Time frame
to see changes in oral mucosa after intake of curcumin for 3 months in cases of oral Leukoplakia, histopathologically & clinically. Since OLP is PMDTimepoint: to see changes on a clinical basis size of the lesion, mouth opening, pain & burning sensation on a monthly basis. Secondly to evaluate histopathologically after 2nd Biospy changes in mucosa after curcumin treatment (Dysplasia decreased or increased)	—

Measure

Time frame

to see changes in oral mucosa after intake of curcumin for 3 months in cases of oral Leukoplakia, histopathologically & clinically. Since OLP is PMDTimepoint: to see changes on a clinical basis size of the lesion, mouth opening, pain & burning sensation on a monthly basis. Secondly to evaluate histopathologically after 2nd Biospy changes in mucosa after curcumin treatment (Dysplasia decreased or increased)

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Countries

India

Contacts

Public ContactDr Anshu Gupta Devra

Sharda University

m.siddharth@sharda.ac.in9810256106

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026