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Comparing pain relieving potential of giving Dexamethasone or Dexmedetomidine or Ketamine when given with 0.375% Ropivacaine for ultrasound guided erector spinae block in spinal surgery for pain relief

Comparison of Efficacy of Dexamethasone vs Dexmedetomidine Vs Ketamine as Adjuvants to Ropivacaine 0.375% for Bilateral Ultrasound guided Erector Spinae Block for Spinal Instrumentation Surgery- A Randomized Controlled Trial - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/09/057570
Enrollment
105
Registered
2023-09-13
Start date
Unknown
Completion date
Unknown
Last updated
2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M259- Joint disorder, unspecified

Interventions

Intervention1: Bilateral ESP Block with Dexmedetomidine: Patients will receive Erector Spinae Block with 0.375% ropivacaine & dexmedetomidine 0.8 mcg/kg ( maximum 50 mcg) combined to total volume of 4

Sponsors

Institute of Neurosciences Kolkata
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Aged 18–65 years ASA grade I, II Either gender BMI Surgical procedure: spinal instrumentation surgeries involving the dorso-lumbar spine (D10-S1) Duration of surgery: up to 4 hours

Exclusion criteria

Exclusion criteria: Patient refusal ASA Grade III/ IV Surgeries: Scoliosis correction surgery Spinal instrumentation surgery planned under intraoperative neuro-monitoring Revision spine surgery Duration of surgery >4 hours, Patients with hypersensitivity to any of the drugs in use History of congestive heart failure/ valvular heart disease/ IHD/ cardiac conduction block/ renal dysfunction/ hepatic disease/ pulmonary disease/ neuropsychiatric disorders/ coagulation abnormality Puncture site infection History of chronic pain or central neuropathy

Design outcomes

Primary

MeasureTime frame
Assessment of duration of analgesia using VAS pain scoreTimepoint: 0 hr 2 hr 4 hr 8 hr 12 hr 24 hr

Secondary

MeasureTime frame
Total intraoperative and postoperative opioid consumptionTimepoint: 24 hr;Intraoperative haemodynamic stabilityTimepoint: 10 min 20 min 30 min 1 hr 1.5 hr 2 hr 2.5 hr 3 hr 3.5 hr 4 hr;First request of rescue analgesicTimepoint: Anytime in first 24 hr;Occurrence of PONV in postoperative periodTimepoint: Anytime in first 24 hr

Countries

India

Contacts

Public ContactDr Kallol Deb

Institute of Neurosciences Kolkata

kalloldeb15@gmail.com9830028915

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026