A clinical trial to compare the effects of low-dose Ketamine and Dexmedetomidine on the need for intraoperative opioids in patients undergoing laparoscopic surgeries

Comparison between low-dose Ketamine and Dexmedetomidine on intraoperative opioid requirement in patients undergoing laparoscopic surgeries - A Randomised Control Trial - Nil

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/09/057337

Enrollment

Registered

2023-09-06

Start date

Unknown

Completion date

Unknown

Last updated

2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intravenous low-dose Ketamine: Patients will be administered an intravenous bolus of Ketamine 0.2mg/kg (5 minutes after pneumoperitoneum) followed by 0.2mg/kg/hr of Ketamine as an intra

Eligibility

Inclusion criteria

Inclusion criteria: Age: 18 - 60 years, ASA 1 and 2 patients, Patients who are undergoing laparoscopic surgeries, Patients without local anaesthetic allergy

Exclusion criteria

Exclusion criteria: Patients with allergy to any of the study agents, ASA 3 and above patients, BMI >45, History of epilepsy, Patients with cardiac/renal/liver disease.

Design outcomes

Primary

Measure	Time frame
To compare between Low dose Ketamine and Dexmedetomidine in terms of effective intraoperative opioid requirement (by measuring intraoperative haemodynamics including heart rate, systolic blood pressure, diastolic blood pressure and mean arterial blood pressure)Timepoint: Baseline (0 minute), 5 minutes, 10 minutes, 20 minutes, and every 30 minutes until the end of the surgery.	—

Secondary

Measure	Time frame
To compare post operative pain and post operative nausea & vomiting in the groupsTimepoint: At PACU (0 minute, 1 hour, 2 hours, 3 hours). After shifting to ward (6 hours, 12 hours)	—

Countries

India

Contacts

Public ContactSabari Sundaresan

Jawaharlal Nehru Medical College

drrajeshmane@gmail.com9844131062

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026