Can isotonic bicarbonates reduce the incidence of acute kidney injury in high voltage electric burns?

Use of isotonic bicarbonates in the prevention of acute kidney injury in high voltage electrical burns: a double blind randomised controlled trial - NIL

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/09/057300

Enrollment

Registered

2023-09-06

Start date

Unknown

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: T300- Burn of unspecified body region, unspecified degree

Interventions

Intervention1: Isotonic bicarbonate fluid therapy: All patients in this group will recieve fluid resuscitation using intravenous isotonic bicarbonates for the first 24 hours with a total volume of (4m

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients with high voltage electrical burns ( > 500 volts). 2) Total body surface area involvement >10%

Exclusion criteria

Exclusion criteria: 1) Patient refusal or no informed consent or both 2)Pre-existing kidney disease 3)BMI 30kg/m2 4)Duration between injury and admission time > 24 hours 5) Presence of head injury 6) Diabetes mellitus 7) Patients requiring intubation and mechanical ventilation prior to recruitment

Design outcomes

Primary

Measure	Time frame
To assess average serum creatinineTimepoint: Every 24 hours over first 7 days following randomisation	—

Secondary

Measure	Time frame
Average blood sugars & need for insulin for glycemic controlTimepoint: First 48 hours;Average BUNTimepoint: First 7 days;Incidence of acute kidney injuryTimepoint: First 7 days;Incidence of hypocalcemiaTimepoint: First 7 days;Incidence of hypokalemia or hyperkalemiaTimepoint: First 7 days;Lactates & pCO2Timepoint: At the end of first 24 hours;MortalityTimepoint: First 28 days;Organ failure free daysTimepoint: First 7 days;pHTimepoint: At the end of first 24 hours;Requirement of invasive mechanical ventilationTimepoint: Over duration of ICU stay/ next 28 days;Requirement of renal replacement therapyTimepoint: Over duration of ICU stay/ next 28 days;Total resuscitation volume requirementTimepoint: Over first 24 hours;Total urine outputTimepoint: At the end of first 24 hours	—

Measure

Time frame

Average blood sugars & need for insulin for glycemic controlTimepoint: First 48 hours;Average BUNTimepoint: First 7 days;Incidence of acute kidney injuryTimepoint: First 7 days;Incidence of hypocalcemiaTimepoint: First 7 days;Incidence of hypokalemia or hyperkalemiaTimepoint: First 7 days;Lactates & pCO2Timepoint: At the end of first 24 hours;MortalityTimepoint: First 28 days;Organ failure free daysTimepoint: First 7 days;pHTimepoint: At the end of first 24 hours;Requirement of invasive mechanical ventilationTimepoint: Over duration of ICU stay/ next 28 days;Requirement of renal replacement therapyTimepoint: Over duration of ICU stay/ next 28 days;Total resuscitation volume requirementTimepoint: Over first 24 hours;Total urine outputTimepoint: At the end of first 24 hours

—

Countries

India

Contacts

Public ContactDr Shreya Vinod

All India All India Institute of Medical Sciences, New Delhi

darlongv@yahoo.com9821607809

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026