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To compare the pain relief in patients after operation ,with different doses of Dexmedetomidine (a drug )as added drug to Bupivacaine given in spinal anaesthesia & Bupivacaine alone in Open Uterine surgeries

Comparative study of the duration of post operative analgesia with different doses of intrathecal Dexmedetomidine as adjuvant to 0.5% Hyperbaric Bupivacaine & with Bupivacaine alone in Total Abdominal Hysterectomy surgeries. - randomized double blind study. - NA

Status
Active, not recruiting
Phases
Phase 1Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/09/057299
Enrollment
90
Registered
2023-09-06
Start date
Unknown
Completion date
Unknown
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N852- Hypertrophy of uterus Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Subarachnoid Block: Administration of Subarachnoid Block in Total Abdominal Hysterectomy Surgeries with Dexmedetomidine 5 mcg and 10 mcg as adjuvant to Buoivacaine - 18 months duration

Sponsors

Jubilee Mission Medical College and Research Institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I & ASA II PATIENTS SCHEDULED TOTAL ABDOMINAL HYSTERECTOMY

Exclusion criteria

Exclusion criteria: Patients with baseline Heart rate Patient refusal for study participation . Local infection at injection site. Presence of any coagulopathies or bleeding disorders or patients on anticoagulation. PRESENCE OF NEUROLOGICAL DEFICITS, PERIPHERAL NEUROPATHIES, MYOPATHIES, OR CHRONIC PAIN IN THE OPERATING LIMB. PATIENTS WITH KNOWN ALLERGY TO LOCAL ANAESTHETICS OR TO ANY STUDY DRUGS TO BE USED. HEMODYNAMICALLY COMPROMISED PATIENTS ALCOHOLIC/ PSYCHIATRIC/UNCOOPERATIVE PATIENTS PATIENTS WITH HEPATIC / RENAL OR CARDIOPULMONARY DISORDERS. PATIENTS LESS THAN 5 FEET HEIGHT. TOTAL ABDOMINAL HYSTERECTOMY TAKING > 3 HRS.

Design outcomes

Primary

MeasureTime frame
Dexmedetomidine 10 mcg was a better adjuvant compared to 5 mcg in terms of better post operative analgesia when used as intrathecal adjuvant to Bupivacaine in subarachnoid blockTimepoint: Post operative analgesia assessed every 6 hours after the requirement of first dose of analgesic

Secondary

MeasureTime frame
Onset of sensory block Onset of motor block Level of block achieved Duration of sensory block Duration of motor blockTimepoint: After administration of subarachnoid block Onset of block ever 2 minutes Duration of block every 6 hours

Countries

India

Contacts

Public ContactDr Davies C V

Jubilee Mission Medical College and Research Institute

daviescv@gmail.com9387890689

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026