To compare the effect of intravenous clonidine versus dexmedetomidine on blood pressure and heart rate during laparoscopic cholecystectomy

A randomised controlled trial to compare the effect of intravenous clonidine versus dexmedetomidine on hemodynamic response to pneumoperitoneum during laparoscopic cholecystectomy - nil

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/09/057270

Enrollment

Registered

2023-09-06

Start date

Unknown

Completion date

Unknown

Last updated

2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: General anaesthesia: premedication of receiving clonidine 0.75 µg/ kg in normal saline or dexmedetomidine 0.75 µg/ kg in normal saline(15 min) Control Intervention1: Normal saline: rec

Eligibility

Inclusion criteria

Inclusion criteria: ASA grades I and II

Exclusion criteria

Exclusion criteria: 1. Patients not giving consent 2. Any heart block, preexisting hypertension, cardiovascular disease 3. Hepatic and renal disease 4. Allergies to the drugs used 5. Acute cholecystitis 6. Pregnant ladies and lactating mothers 7. Patients taking clonidine, methyl-dopa, beta-blocking drugs, benzodiazepines, MAO inhibitors 8. Morbidly obese 9. Open cholecystectomy

Design outcomes

Primary

Measure	Time frame
To compare the effect of intravenous clonidine versus intravenous dexmedetomidine on pneumoperitoneum-induced hemodynamic response during laparoscopic cholecystectomyTimepoint: from the giving of study drug till the end of the study	—

Secondary

Measure	Time frame
1) Effect of intravenous clonidine on hemodynamic response during laparoscopic cholecystectomy 2) Effect of intravenous dexmedetomidine on hemodynamic response during laparoscopic cholecystectomy 3) Effect of intravenous normal saline on hemodynamic response during laparoscopic cholecystectomy 4) To compare the effect of all threeTimepoint: before induction to 5 min after extubation	—

Countries

India

Contacts

Public ContactDr Harpreet Babrah

Sri Guru Ram Das Institute of Medical Sciences and Research

drgurleendhaul@gmail.com9780417889

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026