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A study to correlate the changes in Xrays of knee and wrist joints with blood levels of alkaline phosphatase before and after treatment in children with rickets of age 1-6 years.

A Correlation study of X-Ray changes in Wrist and Knee with Serum Alkaline phosphatase Levels in Evaluating progression and activity of Vitamin D Deficient Rickets in Children Aged 1-6 Years. A prospective analytical study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/09/057219
Enrollment
60
Registered
2023-09-01
Start date
Unknown
Completion date
Unknown
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E550- Rickets, active

Interventions

None listed

Sponsors

Emmanuel Mathews
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Any one of the clinical features of rickets enlargement of wrists and ankles, valgus or varus deformities of the knees, bowing of tibia and femur, Harrison groove, Rachitic rosary. Biochemical features of rickets Serum 25-OH Vitamin D S.ALP > 500 IU/L Radiological Features of rickets Xray wrist and knee with Grade 2 or 3 changes according to the rickets severity score. Widening of growth plate Cupping/Splaying/Fraying of metaphysis Generalized osteopenia

Exclusion criteria

Exclusion criteria: Children already on treatment for rickets History of renal or hepatic diseases History of gastrointestinal pathologies including malabsorption Children on any other medications including anti epileptics. Any congenital or bony deformities. Children with weight for age <2SD for age.

Design outcomes

Primary

MeasureTime frame
Xray changes in wrist & knee (Rickets severity score) & Serum alkaline phosphatase levelsTimepoint: 0 week & 10 week—

Secondary

MeasureTime frame
NilTimepoint: Nil—

Countries

India

Contacts

Public ContactEmmanuel Mathews

All India Institute of Physical Medicine and Rehabilitation, Mumbai

amitmhambre@gmail.com9496501071

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026