Comparison of various injections used to treat temporomandibular joint disorders

A comparative evaluation of various intra-articular injectables in the management of temporomandibular disorders- an in vivo study. - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/09/057180

Enrollment

Registered

2023-09-01

Start date

Unknown

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M249- Joint derangement, unspecified Health Condition 2: M249- Joint derangement, unspecified

Interventions

Intervention1: PRP,PROLOZONE and RINGER LACTATE: PRP injection given at 1st visit and 2nd injection given at 3 months. Prolozone injection given at 1st visit , 2nd injection given at 2nd week and thir

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age group- 20-50 yrs 2. Patients willing for voluntary participation & have signed informed consent for thedescribed procedure. 3. Patients having good physical and mental health . 4. Systemically healthy subjects. 5. Patients with moderately severe and chronic( >3 months) pain and jaw dysfunction. 6. Patients having subluxation without reduction. 7. Compromised mouth opening 8. Degenerative joint disease of the TMJ as the primary source of pain.

Exclusion criteria

Exclusion criteria: . Immunocompromised patients. 2. Psychologically compromised patients. 3. Allergy to Local anesthesia. 4. Dental problem or sinus pathology potentially contributing to pain. 5. Active rheumatological condition. 6. Pain due to infection 7. G6PD Defeciency 8. Pregnancy or breast feeding. 9. Osseous defects 10. TMJ disarticulation. 11. Myofascial pain dysfunction as the sole or primary source of pain. 12. Edentulous subjects. 13. Limited opening secondry to extra-articular pathology. 14. Fibromyalagia. 15. Allergy to study medication.

Design outcomes

Primary

Measure	Time frame
To evaluate the reduction in pain, increase in mouth opening , increase in lateral Mandibular exusion & degenerative changes in temporal mandibular joint disorders with subluxation ( locked jaw) without reduction by using Prolozone Injection, PRP injection and ringer lactate Timepoint: baseline,3 months, 6 months	—

Secondary

Measure	Time frame
To compare the PRP ,Prolozone & Ringer lactate injections in terms of reduction in pain, increase in mouth opening , increase in lateral Mandibular exusion & degenerative changes in temporal mandibular joint disorders with subluxation ( locked jaw) without reductionTimepoint: Baseline, 3 months, 6 months	—

Countries

India

Contacts

Public ContactDr Prashant Mehrotra

Sardar Patel post graduate institute of dental and medical sciences

reflectiondentalcare@gmail.com9453954982

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026