Postoperative nausea, vomiting and hemodynamic changes (heart rate and blood pressure) in gynecological laparoscopic surgery without use of opioid

Comparison of opioid free anesthesia on postoperative nausea,vomiting and haemodynamic changes after gynaecological laproscopy - Nil

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/08/057149

Enrollment

Registered

2023-08-31

Start date

Unknown

Completion date

Unknown

Last updated

2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N838- Other noninflammatory disorders ofovary, fallopian tube and broad ligament

Interventions

Intervention1: Fentanyl: Fentanyl 1.5 mcg/kg 5 mins before induction of anaesthesia Control Intervention1: Dexmedetomidine: dexmedetomidine loading dose 1 mcg/kg over 15 mins duration, 5 mins before i

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA grade I and II 2. Scheduled for laparoscopic gynecological surgery under general anesthesia

Exclusion criteria

Exclusion criteria: 1.Known allergy to study drugs 2.Use of antiemetic drugs within 24 hrs of surgery 3.Morbid obesity(BMI >40) 4.Chronic use of opioids 5.Patients with hepatic,renal or cardiovascular dysfunction 6.Psychiatric patients

Design outcomes

Primary

Measure	Time frame
Postoperative nausea & vomitingTimepoint: 24 hour postoperative period	—

Secondary

Measure	Time frame
Hemodynamic changes heart rate systolic blood pressure diastolic blood pressure mean blood pressureTimepoint: Preoperative period, after study drug, after induction, after intubation, after pneumoperitoneum at 15 min intervals, post pneumoperitoneum, after surgery, after extubation	—

Countries

India

Contacts

Public ContactDr Vinit Kumar Srivastava

Apollo Hospitals Bilaspur

drvinit75@gmail.com9755557539

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026