Health Condition 1: C740- Malignant neoplasm of cortex of adrenal gland Health Condition 2: C23- Malignant neoplasm of gallbladder Health Condition 3: C508- Malignant neoplasm of overlappingsites of breast Health Condition 4: C569- Malignant neoplasm of unspecifiedovary Health Condition 5: C787- Secondary malignant neoplasm of liver and intrahepatic bile duct
Conditions
Interventions
Intervention1: Intravenous injection: Diagnostic radiopharmaceutical Ga-68 FAPI (2-3 mCi) pre therapy for disease spread and uptake information.
Ga-68 FAPI PET/CT is also done after every 2 cycles of
Sponsors
Post Graduate Institute of Medical Education and Research, Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: . Patients older than 18 years of age · Confirmed diagnosis: type of carcinoma . Chemo refractory, multiple lesions or unresectable single lesion . Good uptake on diagnostic Ga-68 FAPI PET/CT · Patients In good general condition (Karnofsky performance status of more than 70) · Ready to give written informed consent for the protocol approved by IEC
Exclusion criteria
Exclusion criteria: · Pregnancy or lactation · Poor kidney function · Any other serious illness · An overall survival expectancy of less than 1 month
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Response in the form of tumor size reduction or disappearance of necrosis within the lesion as per PERSIST criteria 2. Reduction in elevated enzymes/ hormones related to tumor type 3. Improved quality of lifeTimepoint: 6-8 weeks post therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Improved quality of life 2. Study survival benefit 3. study Progression free survival/recurrenceTimepoint: follow up in every 6 month | — |
Countries
India
Contacts
Public ContactDr B R Mittal
Post Graduate Institute of Medical Education and Research
Outcome results
None listed