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Understanding the Link Between Stress Hormones and Heart Changes in Patients on Steroids During Pituitary Surgeries: An Observational Study

Prospective observational study on the association between perioperative cortisol level and hemodynamic variables in patients on steroid therapy undergoing pituitary surgeries - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/08/057089
Enrollment
90
Registered
2023-08-30
Start date
Unknown
Completion date
Unknown
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: nil: nil Control Intervention1: nil: nil

Sponsors

Intramural Funds, Sree Chitra Tirunal Institute for Medical Sciences and Technology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Consenting adult patients undergoing surgery for pituitary tumours at Sree Chitra Tirunal Institute for Medical Sciences and Technology 2.ASA (American Society of Anaesthesiologists) class 1,2 and 3 3.GCS 15/15 prior to the surgery

Exclusion criteria

Exclusion criteria: 1.Patient refusal 2.Age less than 18 years, more than 60 years 3.Emergency surgery 4.Patients with Cushing disease, previous history of adrenal insufficiency 5.ASA class 4,5 patients 6.Patients needing steroid supplementation due to other diseases 7.Pregnant and lactating mothers

Design outcomes

Primary

MeasureTime frame
To assess the correlation between perioperative cortisol levels and hemodynamic variables in patients on steroid therapy undergoing pituitary surgeriesTimepoint: Serum cortisol level will be measured Baseline day before surgery 7:30 am on the day of surgery after induction after sphenoid drilling during hypotensive episode—

Secondary

MeasureTime frame
To find the influence of serum cortisol level & steroid therapy, on hemodynamic variables (including episodes of unexplained hypotension, maximum fall in MAP & hypertension) & the incidence of dyselectrolytemias in patients undergoing pituitary surgeries for tumour resectionTimepoint: Hemodynamic variables will be recorded in 10 minute intervals during intraoperative period. Electrolyte & serum lactate level will be measured after induction and at the end of surgery—

Countries

India

Contacts

Public ContactDr Praveen R S

Sree Chitra Tirunal Institute for Medical Sciences and Technology

drunniz@sctimst.ac.in9447662321

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026