Comparing cognition functions of breast surgery patients receiving either ketamine or dexmedetomidine treatment during surgery

Comparison of the effect of intraoperative infusion of sub-anesthetic ketamine and dexmedetomidine on the postoperative cognitive function in patients undergoing modified radical mastectomy – A Randomized controlled trial. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/08/057031

Enrollment

Registered

2023-08-29

Start date

Unknown

Completion date

Unknown

Last updated

2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Administering infusions of subanesthetic ketamine in modified radical mastectomy patients intraoperatively and comparing the neuro cognition status: Neuro cognition status will be asses

Eligibility

Inclusion criteria

Inclusion criteria: 1.Adult patients aged 18 to 65 years undergoing modified radical mastectomy. 2.American society of Anesthesiologists (ASA) status 1-3

Exclusion criteria

Exclusion criteria: 1.History of dementia or Montreal cognition assessment score less than 26 2.severe audio-visual impairments and illiterate patients. 3.Allergy to any of the drugs used in the study including ketamine and dexmedetomidine. 4.patients receiving regional blocks for postoperative analgesia for MRM 5. ischemic heart disease and uncontrolled hypertension, severe pulmonary disease, heart failure (New York Heart Association class > II). 6. History of known psychiatric/ neurodegenerative disorder 7. Hepatic or renal impairment. 8. patients taking sedatives, antidepressants and glucocorticoids

Design outcomes

Primary

Measure	Time frame
Comparison of the cognition status based on preoperative & postoperative Montreal cognition assessment examination scores between a group receiving intraoperative infusion of sub-anesthetic ketamine & a group receiving intraoperative dexmedetomidine infusion in patients undergoing modified radical mastectomyTimepoint: 12 hours before surgery 6 hours after surgery	—

Secondary

Measure	Time frame
1. VAS score 2.intraoperative fentanyl consumption 3.Comparison of the total morphine consumption 4.time to extubation 5.recovery characteristics between the groups using Quality of life questionnaireTimepoint: 1. 3,6,12,24 hours after surgery 2.during surgery 3.during the first twenty four hours after surgery 4.time from end of surgery to removal of laryngeal mask airway or endotracheal tube. 5.at the end of three months.	—

Measure

Time frame

1. VAS score 2.intraoperative fentanyl consumption 3.Comparison of the total morphine consumption 4.time to extubation 5.recovery characteristics between the groups using Quality of life questionnaireTimepoint: 1. 3,6,12,24 hours after surgery 2.during surgery 3.during the first twenty four hours after surgery 4.time from end of surgery to removal of laryngeal mask airway or endotracheal tube. 5.at the end of three months.

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Countries

India

Contacts

Public ContactDr Suman Lata Gupta

Jawaharlal Institute of Postgraduate Medical Education and Research

maneshcharles@gmail.com9962476374

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026