To compare the effect of two different doses of drug known to prevent fall in blood pressure(ondansetron) in caesarean delivery by calculating the dose of injection of blood pressure raising medicine(ephedrine) required to control fall in blood pressure.

Prospective randomised double blinded interventional study to compare the dose of ephedrine required to control hypotension in patients receiving two different doses of ondansetron during elective caesarean section under spinal anaesthesia :At SMS Medical College, Jaipur - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/08/057012

Enrollment

100

Registered

2023-08-28

Start date

Unknown

Completion date

Unknown

Last updated

2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O82- Encounter for cesarean delivery without indication Health Condition 2: O82- Encounter for cesarean delivery without indication

Interventions

Intervention1: Calculating the dose of ephedrine required to control the hypotension in patients receiving two different doses of intravenous ondansetron during lower segment caesarean section under s

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients undergoing elective caesarean section. 2) Age between 18-35 years. 3) Patients belonging to American Society Of Anaesthesiologist(ASA) grade II. 4) Patients consenting to participate.

Exclusion criteria

Exclusion criteria: 1)History of pre eclampsia and eclampsia. 2)Obesity 3)Patients with allergy to drugs used in the study. 4)Patients with contraindication to neuraxial anaesthesia. 5)Patients with history of drug abuse or addictions.

Design outcomes

Primary

Measure	Time frame
1)To determine the difference in total dose of ephedrine required to control hypotension between two different doses of intravenous ondansetron in parturients undergoing elective lower segment caesarean section . 2)To determine the difference in proportion of hypotension between two different doses of intravenous ondansetron in parturients undergoing elective lower segment caesarean section.Timepoint: Baseline 00 minutes(after spinal) 01 minutes 02 minutes 03 minutes 05 minutes 10 minutes 15 minutes 20 minutes 25 minutes 30 minutes 40 minutes 50 minutes 60 minutes	—

Measure

Time frame

1)To determine the difference in total dose of ephedrine required to control hypotension between two different doses of intravenous ondansetron in parturients undergoing elective lower segment caesarean section . 2)To determine the difference in proportion of hypotension between two different doses of intravenous ondansetron in parturients undergoing elective lower segment caesarean section.Timepoint: Baseline 00 minutes(after spinal) 01 minutes 02 minutes 03 minutes 05 minutes 10 minutes 15 minutes 20 minutes 25 minutes 30 minutes 40 minutes 50 minutes 60 minutes

—

Secondary

Measure	Time frame
To determine side effects between both groups -Nausea, Vomiting, shivering, bradycardiaTimepoint: The application of spinal anaesthesia till completion of surgery.	—

Countries

India

Contacts

Public ContactDr Madhu

SMS Medical College and attached Hospitals, Jaipur

rupihar@gmail.com9899785993

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026