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To compare the efficacy of magnesium sulphate and ketamine gargles on incidence and severity of post-operative sore throat following endotracheal intubation.

To compare the efficacy of magnesium sulphate gargles and ketamine gargles on incidence and severity of post-operative sore throat following endotracheal intubation. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/08/056990
Enrollment
120
Registered
2023-08-28
Start date
Unknown
Completion date
Unknown
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Magnesium sulphate: Magnesium sulphate 1.2 g in 20% dextrose water total volume 30 ml. Control Intervention1: Ketamine gargle: Ketamine - 30 mg in 20% dextrose water total volume 30 ml

Sponsors

Dr. Ramesh Kumar P B
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients requiring general anaesthesia with Proseal laryngeal mask airway. 2. Physical status ASA grade I and II.

Exclusion criteria

Exclusion criteria: 1.Patients with history of pre-operative sore throat, asthma, COPD. 2.Patients requiring oropharyngeal, head and neck surgeries. 3.Patients with Body Mass Index > 30 kg/m2. 4.Patients with full stomach or abdominal distension. 5.Patients with gastroesophageal reflux disease. 6.Patients with modified mallampatti class IV, anticipated difficult airway. 7.Patients having allergy to study drugs. 8.Patients who have recently received NSAIDS. 9.Patients having nausea and vomiting. 10.Expected duration of surgery more than 2 hours.

Design outcomes

Primary

MeasureTime frame
Post-operative sore throatTimepoint: Assessed at 0, 2, 4, 24 hrs post-operatively & graded on a four-point scale—

Secondary

MeasureTime frame
Requirement of Analgesics for POST & Side Effects profile of study drugs.Timepoint: VAS scoring POST to be assessed at 0,2,6,24 hours post operatively—

Countries

India

Contacts

Public ContactDr Shruti Rao

BGS Global Institute of Medical Sciences

arunarunagiri12@gmail.com9442225100

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026