To compare effectiveness of two different doses of dexmedetomidine to control blood pressure and heart rate in response to intubation in patients undergoing Elective Cardiac surgery

Comparision of the efficacy of two doses of dexmedetomidine in attenuating the hemodynamic response to intubation in patients undergoing elective coronary artery bypass grafting surgery - A randomized double blinded study - NIL

Status

Recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/08/056971

Enrollment

Registered

2023-08-28

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I20-I25- Ischemic heart diseases

Interventions

Intervention1: Use of Dexmedetomidine 1.5µg/kg IV in CABG: Group D2 (dexmedetomidine) will receive 1.5 µg/kg of intravenous infusion of dexmedetomidine, diluted with normal saline to a total volume of

Eligibility

Inclusion criteria

Inclusion criteria: Age > 30 years Elective CABG

Exclusion criteria

Exclusion criteria: Patient’s refusal to participate. Patients with left ventricular ejection fraction Left main coronary artery occlusion > 50%, Moderate to severe valvular dysfunction. Bradycardia (HR Preoperative medication with a 2 agonist. Anticipated difficult intubation. Intubation attempt would last longer than 15s.

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of two different doses of dexmedetomidine (1ug/kg & 1.5 ug/kg) as 15 minute infusion in attenuating heart rate (HR) to laryngoscopy & intubation in elective CABG surgeriesTimepoint: HR will be measured at baseline 5 minutes afterdrug administration 2 minute after induction agent 1 3 5 7 minutes after intubation	—

Secondary

Measure	Time frame
To assess sedation & any adverse effects seen.Timepoint: sedation will be assessed at baseline 5 minute of infusion at end of infusion	—

Countries

India

Contacts

Public ContactDR ALOK KUMAR BHARTI

Indira Gandhi Institute of Medical Sciences, Patna

alok.bharti48@gmail.com9307645596

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026