Health Condition 1: - Health Condition 2: E101- Type 1 diabetes mellitus with ketoacidosis
Conditions
Interventions
Intervention1: Subcutaneous Basalog along with intravenous regular insulin infusion: The intervention group will receive subcutaneous insulin glargine at a dose of 0.3units / kilogram within 2 hours o
Sponsors
Bharati Vidyapeeth medical college
Eligibility
Inclusion criteria
Inclusion criteria: Children between 1 year and 18 years of age with type 1 DM who are admitted to the pediatric intensive care unit with moderate or severe diabetic ketoacidosis (DKA) as per the ISPAD 2022 guidelines.
Exclusion criteria
Exclusion criteria: - Children with mild DKA. - Children with moderate or severe DKA who have received a dose of glargine insulin within the last 24 hours. - Children who’s parents refuse to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the time taken for resolution of acidosis in between two groups. To calculate and compare the duration of insulin infusion and total IV insulin requirement in between the two groups. Timepoint: From starting of DKA protocol to time of resolution of DKA (pH more than 7.3 and HCO3 more than 18). | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the occurrence of rebound hyperglycemia post transition to subcutaneous insulin in between the two groups. To determine the incidence of complications including hypoglycemia and hypokalemia and compare outcomes in terms of length of PICU stay. Timepoint: From starting of DKA protocol to 6 hours after time of resolution of DKA (pH more than 7.3 and HCO3 more than 18). | — |
Countries
India
Contacts
Public ContactDr Bhakti Sarangi
Bharati Vidhyapeeth (deemed to be University) medical college
Outcome results
None listed