Efficacy of Silver nanoparticle coating in reduction of microbial colonies on the surface of clear aligner

Comparative evaluation of reduction in microbial colonies after nanoparticle coating of clear aligners for S. mutans, P. gingivalis, C. albicans & L. acidophilus - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/08/056937

Enrollment

Registered

2023-08-25

Start date

Unknown

Completion date

Unknown

Last updated

2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K038- Other specified diseases of hard tissues of teeth

Interventions

Intervention1: SILVER NANOPARTCLE COATING ON SAMPLES OF CLEAR ALIGNERS: 100nm THICKNESS ON THE INNER SURFACE OF ALIGNERS Pt will be asked to wear one set of aligners for a period of 14 days Control I

Eligibility

Inclusion criteria

Inclusion criteria: 1. Arch length-tooth material discrepancy = 4 mm 2. Non extraction plan 3. Localised/Generalized spacing 4. Patients aged 15-35 years

Exclusion criteria

Exclusion criteria: 1. Arch length-tooth material discrepancy > 4mm 2. Poor periodontal health 3. Age more than 35 years 4. Previous history of orthodontic treatment 5. History of Systemic disease 6. Non-compliant patient

Design outcomes

Primary

Measure	Time frame
To evaluate microbial count for Streptococcus mutans, Candida albicans, Porphyromonas gingivalis & Lactobacillus acidophilus over AgNP coated aligner over a period of 14 days of intraoral usage & compare the microbial count for these microorganisms with uncoated sample of aligners. Timepoint: Uncoated sample: At baseline and 2 weeks Coated sample: At 2 weeks and 4 weeks	—

Secondary

Measure	Time frame
To evaluate & compare number of microbial colonies in saliva over a period of 14 days wear of silver nanoparticle coated clear aligners with that of uncoated alignersTimepoint: Saliva sample collection for uncoated clear aligners: Day 0, day 3, day 10, day 14 Saliva sample collection for coated clear aligners: Day 14, day 17, day 24, day 28	—

Countries

India

Contacts

Public ContactDr Sunanda Roychoudhury

Shree Bankey Bihari Dental College & Research Centre

sunanda.9@hotmail.com9810007709

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026