Health Condition 1: F20- Schizophrenia
Conditions
Interventions
None listed
Sponsors
DrAkhila Soman
Eligibility
Inclusion criteria
Inclusion criteria: Diagnosed patients of Unmada according to Ayurveda and patients of Schizophrenia as per DSM-5-TR Patients with predominant Negative symptoms (Any of the 4 Global scores of Scale for the Assessment of Negative Symptoms- SANS= 3). Mild or lesser level of positive symptoms (Global score of all items of Scale for the Assessment of Positive Symptoms SAPS Patients who are in the capacity to provide informed consent (as assessed by UBACC- University of California, San Diego Brief Assessment of Capacity to Consent (UBACC) will be recruited. Those who do not have the capacity, caregiver’s consent will be taken. Patients who are on stable medications for atleast 1 month.
Exclusion criteria
Exclusion criteria: Patients with bipolar affective disorder, substance use disorders (except nicotine and caffeine), major systemic illness, neurological disorders and immune system disorders. Patients with suicidal tendencies. Patients scoring > 7 in Hamilton Depression Rating Scale. Pregnant and lactating mothers. Patients unsuitable for Vamana procedure – heart diseases, severe hepatic, renal or pulmonary dysfunction. Patients who have undergone Vamana or Virechana karma in the last 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate clinical efficacy of Vamana and Virechana karma in patients of Schizophrenia with predominant negative symptoms, in comparison to treatment as usual group using Scale for assessment of Positive Symptoms (SAPS) and Scale for assessment of Negative Symptoms(SANS) Timepoint: Baseline, after 3 days of intervention and after 1 month of intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| a) To study the effect of Vamana & Virechana karma on functioning, physical health (BMI), acute changes in physiological (CRP & HRV) parameters after 3 days of vamana/virechana karma in patients of Schizophrenia with predominant negative symptoms b) To evaluate the sustenance of improvement in terms of physical health (BMI), acute changes in physiological (CRP & HRV) after 1 month of Vamana & Virechana karma in patients of Schizophrenia with predominant negative symptoms.Timepoint: Baseline, after 3 days of intervention & after 1 month of intervention | — |
Countries
India
Contacts
Public ContactDrAkhila Soman
NIMHANS
Outcome results
None listed