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Comparison of the effectiveness of proteolytic enzymes and diclofenac in patients with impacted third molars in the mandible.

Comparison of efficacy of combinations of proteolytic enzymes (trypsin, bromelain, and rutoside) and diclofenac versus serratiopeptidase and diclofenac versus diclofenac alone in patients with similar Pederson’s difficulty index impacted mandibular third molars in a randomised control double blind trial - NIL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/08/056907
Enrollment
60
Registered
2023-08-24
Start date
Unknown
Completion date
Unknown
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Proteolytic Enzymes (Bromelain, Trypsin, Rutoside , Serratiopeptidase) and Diclofenac: Tab (Trypsin 48mg, Bromelain 90mg, Rutoside 100mg) and Tab Diclofenac 50mg BD for 5 Days Tab Serra

Sponsors

Dr Ramkrishn Yadav
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1)Mandibular third molar impacted patients with the similar Pedersons difficulty index. 2)Age group of 18 to 40 years. 3)Patient coming under category of ASA I 4)The medications or anesthetics that will be utilized in the surgical regimen have not contraindications. 5)Patients who are willing to accept informed consent and are willing to participate in the study with its subsequent follow ups will be included in this study.

Exclusion criteria

Exclusion criteria: 1)Patients with systemically compromised health. 2)Pregnant and lactating women. 3)Patients allergic to NSAIDS. 4)Patients on anticoagulant therapy. 5)Patient coming under category of ASA II, III, and IV.

Design outcomes

Primary

MeasureTime frame
The best drug regimen among proteolytic enzymes with diclofenac in reducing post-operative complication like Pain, Swelling Trismus following Surgical extraction of Mandibular third molarTimepoint: Post operative 1st 3rd 5th 7th days

Secondary

MeasureTime frame
pain, swelling, trismus,Timepoint: 0,1,3,5,7 days

Countries

India

Contacts

Public ContactDr Ramkrishn Yadav

Government Dental College Raipur (C.G.)

sanjayjadwani177@gmail.com9893550777

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026