Safety and efficacy of deep breathing to oxygenate patient before induction of anaesthesia to measure fall in oxygen saturation time and rise in carbon dioxide levels by an observational study

Assessment of effectiveness and safety of deep breathing(DB)preoxygenation on apnoeic oxygen desaturation(SPO2) time and end tidalCO2(ETCO2) following induction of general anaesthesia:An observational study - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/08/056901

Enrollment

Registered

2023-08-24

Start date

Unknown

Completion date

Unknown

Last updated

2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: R688- Other general symptoms and signs

Interventions

Intervention1: PREOXYGENATION WITH OXYGEN: Its an observational study . Patients ASA and MP grade 1 will undergo deep breathing(DB) preoxygenationat flow rate of 10 lit /minute(2) with 12 breath b

Eligibility

Inclusion criteria

Inclusion criteria: American society of anaesthesia grade 1 patient will be included with no comorbid state with malampatti airway assessment grade 1 undergoing various surgical procedure in elective setting.All patient above ASA grade 1 and malampatti grade 1 were excluded from the study.Only patient with haemogloin 10gm %or above will be included in the study

Exclusion criteria

Exclusion criteria: Patients with any comorbidity ,smokers, BMI >25,American Society of Anaesthesia Grade 2(ASA),Mallampatti Grade >1,Pregnency,Haemoglobin <10gm%

Design outcomes

Primary

Measure	Time frame
1.Measure time available for aponic oxygen desaturation to fall of spo2 to 94% after deep breathing preoxygenation(DB)12 with oxygen 10 lit/minute during aponic period. 2.To measure Build up of ETCO2 at the end of Aponic period 3. Time take or number of breath to achieve ET02 of 90 % Timepoint: 1BASAL OXYGEN SATURATION -At begining of preoxygenation on air 2.OXYGEN SATURATION At end of 12 deep breath 3.Measure time available for aponic oxygen desaturation to fall of spo2 to 94% after deep breathing preoxygenation(DB)12 with oxygen 10 lit/minute during aponic period. 4.To measure Build up of ETCO2 at the end of Aponic period from basal level at end of 12 deep breath 5. Basal ET02 and time or number of breath taken to achieve ET02 of 90 %	—

Measure

Time frame

1.Measure time available for aponic oxygen desaturation to fall of spo2 to 94% after deep breathing preoxygenation(DB)12 with oxygen 10 lit/minute during aponic period. 2.To measure Build up of ETCO2 at the end of Aponic period 3. Time take or number of breath to achieve ET02 of 90 % Timepoint: 1BASAL OXYGEN SATURATION -At begining of preoxygenation on air 2.OXYGEN SATURATION At end of 12 deep breath 3.Measure time available for aponic oxygen desaturation to fall of spo2 to 94% after deep breathing preoxygenation(DB)12 with oxygen 10 lit/minute during aponic period. 4.To measure Build up of ETCO2 at the end of Aponic period from basal level at end of 12 deep breath 5. Basal ET02 and time or number of breath taken to achieve ET02 of 90 %

—

Secondary

Measure	Time frame
1.Changes in heart rate & blood pressue (MAP)during apnoic oxygenation following intubation from basal at every 2 minutes. 2.Saftey of patients during apnoic oxygenation period in terms of arrythemias Timepoint: 1.Changes in blood pressure ,pulse & mean arterial pressure from basal to every 2 minutes before & after induction of general anaesthesia & during apnoeic period 2.Cardiac arrhythmias noted by continous ECG monitoring at any time	—

Measure

Time frame

1.Changes in heart rate & blood pressue (MAP)during apnoic oxygenation following intubation from basal at every 2 minutes. 2.Saftey of patients during apnoic oxygenation period in terms of arrythemias Timepoint: 1.Changes in blood pressure ,pulse & mean arterial pressure from basal to every 2 minutes before & after induction of general anaesthesia & during apnoeic period 2.Cardiac arrhythmias noted by continous ECG monitoring at any time

—

Countries

India

Contacts

Public ContactDr SATYENDRA YADAV

VCSG GOVT MED SCI AND RESEARCH INSTITUTE

satyendra.homein@gmail.com09410110479

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026