Health Condition 1: F20-F29- Schizophrenia, schizotypal, delusional, and other non-mood psychotic disorders
Conditions
Interventions
Intervention1: oral probiotics plus prebiotics capsules: One group (Test) will be given one oral Synbiotic capsules daily with breakfast and one synbiotic capsule with dinner along with standard Antip
Sponsors
Government Medical College Patiala Punjab
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients taking antipsychotics and adjunct medication. Patients diagnosed with schizophrenia spectrum and other psychotic disorders defined under DSM-5 (Diagnostic and statistical manual of mental disorders). Patients of age group of 18-45 years. Patients having = 5% weight gain after start of antipsychotics.
Exclusion criteria
Exclusion criteria: Patients who refuse to give consent for the use of study. o Patients already taking probiotic and prebiotic supplements. o Patients with diagnosed with gastrointestinal tract disorder. Patients with history of metabolic or chronic medical illness like Diabetes Mellitus, Hypertension, Thyroid disorders etc. Patients who are pregnant or planning to become pregnant during the study period. Patients with history of substance use disorder. Patients with history of antibiotic medication intake, 14 days prior to study (as anaerobic organisms residing in the gastrointestinal tract may be affected by antibiotics). Patients who participated in any investigational drug trial in the past 30 days. Patients not on any oral hypoglycemics or other weight lowering medication like Metformin, Topiramate etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the effects of use of oral Synbiotics in Antipsychotic induced weight gain in Schizophrenia Spectrum & other Psychotic Disorder patients as per DSM 5 Diagnostic & statistical manual of mental disorders To evaluate the effects of Synbiotics as adjuvant treatment on lipid profile & fasting blood sugar in psychotic patients taking antipsychotics Timepoint: outcome will be assessed/estimated in four readings i.e. at baseline, 4 weeks ,8 weeks and 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare BPRS (Brief Psychiatric Rating Scale ) Score in psychotic patients taking synbiotics & antipsychotics versus antipsychotics alone.Timepoint: outcome will be assessed/estimated in four readings i.e. at baseline, 4 weeks ,8 weeks & 12 weeks | — |
Countries
India
Contacts
Public ContactDr Mehtab Singh Bal
Government Medical College Patiala
Outcome results
None listed