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To compare the effect of bous intravenous dose of Dexmedetomidine versus Magnesium Sulphate on induction dose of Propofol in patients undergoing general anaesthesia

Comparing the effect of bolus intravenous Dexmedetomidine versus Magnesium Sulphate on induction dose of Propofol-A Randomised Controlled Trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/08/056866
Enrollment
75
Registered
2023-08-24
Start date
Unknown
Completion date
Unknown
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K35-K38- Diseases of appendix Health Condition 2: K20-K31- Diseases of esophagus, stomach and duodenum Health Condition 3: K00-K14- Diseases of oral cavity and salivary glands Health Condition 4: H60-H95- Diseases of the ear and mastoid process Health Condition 5: N60-N65- Disorders of breast Health Condition 6: K80-K87- Disorders of gallbladder, biliary tract and pancreas Health Condition 7: K40-K46- Hernia

Interventions

Intervention1: PROPOFOL DEXMEDETOMIDINE AND MANESIUM SULPHATE: INJECTION PROPOFOL INTRAVENOUS ROUTE Control Intervention1: DEXMEDETOMIDINE MAGNESIUM SULPHATE NORMAL SALINE: 1.INJECTION DEXMEDETOMIDIN

Sponsors

DR ANAND S
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: a. ASA Grade I and Grade II patients b. Age 18 yrs –60yrs. c. Elective surgeries

Exclusion criteria

Exclusion criteria: a. Refusal of consent b. Known or anticipated difficult airway. c. Emergency surgeries. d. Pregnant patients. e. Patients with heart block f. Patients on Beta blockers g. Bradycardia h. BMI >30kg/m2

Design outcomes

Primary

MeasureTime frame
For comparing the dose of Propofol needed during induction of anaesthesia after giving a bolus dose of Dexmedetomidine or Magnesium Sulphate or Normal saline in general anaesthesiaTimepoint: Baseline,After Drug bolus,After propofol induction—

Secondary

MeasureTime frame
a) To check the intubation response between the three groups-heart rate,blood pressure,saturation. b) Time required for TOF value to change from 0 to 1 Timepoint: Preintubation vitals,post intubation vitals at 1,2,3,5 minutes Time required for recovery from muscle relaxant after intubation dose—

Countries

India

Contacts

Public ContactDR.HARSHANAA.G

CHETTINAD ACADEMY OF RESEARCH AND EDUCATION

dranandmurugan@gmail.com9444486183

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026