Induction chemotherapy followed by radiotherapy in locally advanced head and neck cancers.

Simultaneous Modulated Accelerated Radiotherapy with Induction Chemotherapy in LAHANC- A Prospective Study - nil

Status

Recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/08/056851

Enrollment

Registered

2023-08-23

Start date

Unknown

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C01- Malignant neoplasm of base of tongue

Interventions

Intervention1: Neoadjuvant Chemotherapy Followed by simultaneous Modulated Radiotherapy: 3 cycle DCF Regiment followed by EBRT HR_66Gy/30#, IR_60GY/30#, LR_54Gy/30# Control Intervention1: NA: NA

Eligibility

Inclusion criteria

Inclusion criteria: 1)Histologically proven oropharynx, larynx, hypopharynx cancer 2)Stage III-IV 3)Squamous cell carcinoma 4) ECOG 0-1

Exclusion criteria

Exclusion criteria: 1) Previously treated Head and Neck Malignancy 2) Pregnant Lactating Females 3) Received chemotherapy and radiotherapy earlier

Design outcomes

Primary

Measure	Time frame
1)loco regional control 2) Acute toxicity 3) quality of LifeTimepoint: 6 months	—

Secondary

Measure	Time frame
1) overall survival 2) Disease free survival 3)late toxictyTimepoint: 6 months	—

Countries

India

Contacts

Public ContactDr Sunil Choudhary

IMS, BHU

drsunil104@gmail.com9559481453

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026