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Association of genetic variation of GABRA genes with blood pressure and heart rate in patients receiving propofol during general anaesthesia

Association of genetic polymorphisms of GABRA1 and GABRA2 genes and hemodynamic responses to propofol in patients undergoing general anaesthesia. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/08/056839
Enrollment
94
Registered
2023-08-23
Start date
Unknown
Completion date
Unknown
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

Maulana Azad Medical College and Associated Lok Nayak Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients fulfilling criteria for American Society of Anaesthesiologists(ASA) physical status I-II 2. Age 18-60 years 3. Body mass index (BMI) 20-30kg/cm2

Exclusion criteria

Exclusion criteria: 1.Hypertension and any cardiac disease 2.Pregnancy 3.Psychiatric illness or patient suffering from intellectual disability. 4.H/O allergy to propofol 5.H/O substance abuse (alcohol) 6.Neurosurgery

Design outcomes

Primary

MeasureTime frame
To assess the association of genotypes CC,GC,GG of GABRA2 rs11503014 gene with post induction hypotension with propofol in patients undergoing general anaesthesia.Timepoint: 0 minute , every minute thereafter till 8 minutes, 10 minutes, 15 minutes—

Secondary

MeasureTime frame
1.To study the relationship between genotypes AA, AG, GG of GABRA1 rs2279020 gene & genotypes TT, TC, CC of GABRA1 rs1157122 with hypotension after induction of anaesthesia with propofol. 2.Total requirement of fluid for correcting hypotension induced by propofol during anaesthesia. 3.To determine ephedrine requirement for hypotension not responding to fluid boluses. Timepoint: 0 minute , every minute thereafter till 8 minutes, 10 minutes, 15 minutes—

Countries

India

Contacts

Public ContactDr Samikshya Suman

Maulana Azad Medical College

kirtinath@gmail.com9968604215

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026