Health Condition 1: K740- Hepatic fibrosis
Conditions
Interventions
Intervention1: Low dose albumin: Albumin will be given at a low dose of albumin 0.5gm/kg for 3 days.
Albumin (0.5g/kg) will be given for another two days in case of AKI based on IVC diameter.
Control
Sponsors
AIG Hospitals
Eligibility
Inclusion criteria
Inclusion criteria: Patient >18 years age and cirrhosis and ascites with PMN count >250/cumm in the absence of secondary bacterial peritonitis. Patient with SBP diagnosed in our hospital.
Exclusion criteria
Exclusion criteria: Patients less than 18 years of age Hepatocellular carcinoma or peritoneal carcinomatosis Tuberculosis, pancreatitis or bleeding into ascitic fluid (which can elevate the PMN count in ascitic fluid). Cardiac or end-stage kidney disease. Patients with SBP diagnosed in outside hospital Secondary bacterial peritonitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In-hospital mortality among both the groupsTimepoint: Duration of hospital stay | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in serum Albumin level Timepoint: at day 3;Cost of albumin in each group Timepoint: For the duration of hospital stay;Duration of hospital & ICU stay. Timepoint: total duration of hospitalization & ICU stay;Incidence of adverse events in each group Timepoint: During the hospital stay;Incidence of AKI & Hepatic encephalopathy in each group. Timepoint: During the hospital stay;Proportion of patients requiring albumin infusions for an extended duration. Timepoint: at day 5;Proportion of patients responding to therapy in each group Timepoint: after 48 hours & at 5 days in case of no response at 48 hours | — |
Countries
India
Contacts
Public ContactDr Vidish Sheth
Asian Institute of Gastroenterology Hospitals.
Outcome results
None listed