To analyse the effect of prophylactic combination of Glycopyrrolate, Ondansetron and Ephedrine in minimizing hypotension during obstetric spinal anaesthesia.

A comparative study to assess the efficacy of combination of Glycopyrrolate, Ondansetron and Ephedrine in prevention of hypotension following obstetric spinal anaesthsia in terms of need for therapeutic dose of Ephedrine- a randomized, double blind, controlled study in Department of Anaesthesiology, SMS Medical College, Jaipur. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/08/056746

Enrollment

Registered

2023-08-22

Start date

Unknown

Completion date

Unknown

Last updated

2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O82- Encounter for cesarean delivery without indication

Interventions

Intervention1: Prophylactic injection prior to spinal anaesthesia: Injection Glycopyrrolate 200 micrograms, Injection Ondansetron 4 milligrams and Infusion Ephedrine 1 milligram per minute before givi

Eligibility

Inclusion criteria

Inclusion criteria: 1. Parturients aged 20-35 years. 2. parturients belong to ASA Grade I and II 3. Parturients undergoing elective caeserean section under spinal anaesthesia. 4. Parturients willing to participate in the study.

Exclusion criteria

Exclusion criteria: 1. Parturients with contraindications to spinal anaesthesia. 2. Parturients with history of allergy to study drugs. 3. Parturients with pregnancy induced hypertention 4. Parturients with multiple gestations and abnormal placentation. 5. Parturients with height less than 145cm

Design outcomes

Primary

Measure	Time frame
1. Mean total dose of ephedrine required intra operatively in both the groups. 2. Mean number of hypotension episodes between the period of induction & delivery of baby in both the groups. 3. Mean number of bradycardia episodes in intra operative period in both the groups. Timepoint: 90 minutes	—

Secondary

Measure	Time frame
1. Neonatal APGAR scores at 0 & 3min. 2. Delivery time in both the groups. 3. Adverse events in both the groups, if any.Timepoint: 90 minutes	—

Countries

India

Contacts

Public ContactDr Tontanga Momoson Maring

Sawai Man Singh Medical College Jaipur

chatterjee.chandrashekhar@gmail.com9828088092

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026