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To study the blood flow in the brain during surgery with the help of ultrasound.

Comparison of Cerebral Blood Flow During Recovery Between Total Intravenous Anesthesia Versus Balanced Anesthesia Technique in Patients Undergoing Elective Supratentorial Craniotomy: A Randomized Controlled Trial - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/08/056679
Enrollment
50
Registered
2023-08-21
Start date
Unknown
Completion date
Unknown
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: C00-D49- Neoplasms

Interventions

Intervention1: BALANCED ANAESTHESIA: Group B will receive Propofol schnider effect site concentration of 2-3 titrated to a BIS of 40-60 and Fentanyl 1-2 mcg/kg/hr along with Sevoflurane MAC of 0.5. C

Sponsors

Christian Medical College Vellore
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 17-65years 2. Supratentorial tumor with no clinical /radiological features of raised ICP-MLS 3. ASA 1,2,3

Exclusion criteria

Exclusion criteria: 1. Emergency Procedure 2. Severe cardiovascular or respiratory disease (ASA grade =3), 3. Poor visulalization of MCA due to inadequate temporal window, 4. Pregnancy, 5. Allergies to Propofol, 6. History of Renal, Liver disease, 7. Psychiatric illnesses, 8. Patient refusal, 9. Awake Craniotomy, 10. GCS 11. Preoperative Cognitive defects/Vision Loss 12. Symptomatic Raised Intracranial Pressure with hypertension and Bradycardia 13. Patients on ventilator preoperatively

Design outcomes

Primary

MeasureTime frame
To evaluate the effect of anaesthesia, which is either TIVA with propofol or balanced anesthesia with Sevoflurane on cerebral blood flow by transcranial doppler (TCD) measurement of Mean Flow Velocity (MFV) of middle cerebral artery (MCA) in patients undergoing elective supratentorial craniotomy.Timepoint: 1. baseline before anaesthesia, 2. after intubation 3. postoperatively within 30 minutes after extubation 4. postoperatively within 60 minutes after extubation and 5. on postoperative day 2 - 5—

Secondary

MeasureTime frame
1. Perioperative measurement of cerebral autoregulation 2. Intra-operative hemodynamic profile 3. Time taken to attain preoperative GCSTimepoint: 1) Cerebral autoregulation using THRT test in the preoperative period, immediate (60 minutes) & late (3-6 days) postoperative period. 2) Intraoperative Haemodynamic Profile HR & MAP will be recorded every 15 minutes from the baseline throughout the surgery, at the time of discontinuation (D/C) of IV or volatile agent (VA), at the time of emergence, till 60 minutes after extubation & post-operative between day 2-5.—

Countries

India

Contacts

Public ContactSelvendiran P

Christian Medical College, vellore

keta0819@gmail.com9879520603

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026