To compare effectiveness of dexmeditomidine versus nalbuphine for pain relief in spinal anaesthesia after lower limb surgeries

To compare the efficacy of intrathecal dexmedetomidine versus nalbuphine for postoperative analgesia in patients undergoing lower limb surgeries - nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/08/056624

Enrollment

Registered

2023-08-18

Start date

Unknown

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group A: Intrathecal 15 mg hyperbaric 0.5% levobupivacaine + inj. nalbuphine 400 mcg Intervention2: Group B: Intrathecal 15 mg hyperbaric 0.5% levobupivacaine +inj. dexmedetomidine 10 m

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients who are consenting for the study 2. Patients undergoing lower limb surgeries 3. American Society of Anesthesiology (ASA) Grade I and II

Exclusion criteria

Exclusion criteria: 1. Contraindications to regional anaesthesia such as anatomic disorders of spine, shock, coagulation and bleeding disorders, local site infections. 2. Patients with hypersensitivity to study drugs 3. Pregnant female 4. Patients with the history of neuropsychiatric problems 5. Patients with communication problems that will not able to understand visual analogue scale (VAS). 6.Patients refusing for consent.

Design outcomes

Primary

Measure	Time frame
Post-operative analgesia with dexmedetomidine & nalbuphine as adjuvants combined with 0.5 percent hyperbaric levobupivacaine in spinal anesthesia.Timepoint: till 24 hours	—

Secondary

Measure	Time frame
To evaluate dexmedetomidine & nalbuphine in terms of onset, duration of sensory and motor block, postoperative analgesic effect, sedation score, side effects of study drugsTimepoint: till 24 hours	—

Countries

India

Contacts

Public ContactDr Pooja Abbi

Sri Guru Ram Das Institute of Medical Sciences and Research

gugneet.kaur757@gmail.com7589135002

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026