A Comparison between three different doses of clonidine for decreasing stress response to endotracheal intubation during surgery

Efficacy of three different doses of clonidine for attenuation of hemodynamic stress response to laryngoscopy and endotracheal intubation in surgeries under general anesthesia - NIL

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/08/056600

Enrollment

168

Registered

2023-08-17

Start date

Unknown

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: Attenuation of sympathoadrenal response to endotracheal intubation by drugs at 1, 3 and 5 minutes after intubation: Comparing three different doses of intravenous Clonidine for attenuat

Eligibility

Inclusion criteria

Inclusion criteria: 1.American Society Of Anaesthesiology (ASA) 1 and 2.Elective surgical Procedures 3.Either Sex 4.Consenting Adults Of age 18 to 55 Years

Exclusion criteria

Exclusion criteria: 1.Known sensitivity to any study drug 2.Pregnant females 3.Pateint with chronic hypertension and diabetes mellitus 4. Patient with history of cardiac and respirtaory disease 5.Patient with anticipated difficult airway 6.Patient with impaired kidney and liver function

Design outcomes

Primary

Measure	Time frame
Hemodynamic Response to Endotracheal Intubation (Heart rate, SBP & DBP, MAP)Timepoint: Hemodynamic Response to Endotracheal Intubation (Heart rate, SBP & DBP, MAP) after 1 and 3 and 5 minute of endotracheal intubation	—

Secondary

Measure	Time frame
Biochemical markers of stress response (Serum Cortisol & Blood glucose levels)Timepoint: 5 minutes following Laryngoscopy & Endotracheal intubation	—

Countries

India

Contacts

Public ContactMohit Kumar Yadav

ABVIMS and Dr.RML Hospital

lalitachaudhary055@gmail.com9968299710

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026