Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery
Conditions
Interventions
Intervention1: Gabapentin: 600mg 2 doses, 12 hours apart, on the night before and morning of surgery
Control Intervention1: Placebo: 2 doses, 12 hours apart on the day before and morning of surgery
Co
Sponsors
Anita Josprakash
Dr Shibu C Kallivalappil
Eligibility
Inclusion criteria
Inclusion criteria: 1. Elective CABG 2. Same surgical and anaesthetic team 3. Beating Heart Surgeries 4. Age between 35 and 70 years 5. BMI less than 35kg/m2 6. Ejection Fraction greater than 30%
Exclusion criteria
Exclusion criteria: 1. Patient refusal to participate in the study 2. Patients with history of allergic reaction to gabapentin 3. Pregnant females 4. Patients posted for emergency surgeries, history of previous sternotomy or patients undergoing re-exploration sternotomy 5. Patients with history of comorbid diseases like neurological, psychiatric disorder or Alcohol dependence. 6. Patients with history of taking gabapentin or pregabalin in the past 3 months and chronic analgesic use, including opioids, NSAIDs or paracetamol etc. 7. Renal insufficiency (Serum Creatinine greater than 1.8)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To measure the opioid requirement intraoperatively & postoperatively 2. Pain scores at 0,1,3,6,12,24,36,48 & 72 hours after extubationTimepoint: 5 days | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Postoperative Quality of Recovery. 2) Postoperative Nausea & vomiting. 3) Hyper-sedation. 4) Prolongation of mechanical ventilation.Timepoint: 5 days | — |
Countries
India
Contacts
Public ContactDr Shibu C Kallivalappil
Jubilee Mission Medical College and Research Institute
Outcome results
None listed