Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Neuromuscular blockade reversal using Sugammadex: At the end of surgery, we will give Injection Sugammadex 2mg/kg intravenously for reversal of neuromuscular blockade in 30 patients (Gr
Sponsors
Department of Anaesthesia
Eligibility
Inclusion criteria
Inclusion criteria: Patients undergoing elective surgeries under general anaesthesia ASA Grade I & II Duration of anaesthesia <2 hours.
Exclusion criteria
Exclusion criteria: Patients with known allergies to multiple drugs. Pregnant/Nursing mother. Age 60 years. Patients with history of renal or hepatic disease. Patients with a history of arrhythmia, neurological disorder, acute or chronic alcoholism or neuromuscular disorders, patients with cardiac pacemaker. Allergic/Hypersensitivity to Neostigmine or Sugammadex. Diaphragmatic palsy Emergency, Cardiac, liver or lung transplant surgery. Morbidly obese patients (BMI >= 35.5 kg/m²) On current Medications with drugs having effects on nervous system. Patient refusal Severe bradycardia. Thrombocytopenia. Blood Dyscrasias or coagulopathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the safety & efficacy of sugammadex versus neostigmine for reversal of neuromuscular blockade. To assess recovery time from the administration of study drug to train of four ratio (TOF) of 0.9. To assess post-operative residual paralysis. To compare hemodynamic effects of sugammadex & neostigmineglycopyrrolate combination in adult patients.Timepoint: Time from administration of muscle relaxant till 6 hours after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Drug related adverse events (if any)Timepoint: Time from administration of muscle relaxant till 6 hours after surgery | — |
Countries
India
Contacts
Public ContactDr Anu Sharma
Government Medical College, Amritsar
Outcome results
None listed