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Effect of Aspirin on baby inside the womb during pregnancy and after delivery.

Influence of fetal and perinatal ductal flow dynamics with and without maternal low dose Aspirin. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/08/056361
Enrollment
200
Registered
2023-08-10
Start date
Unknown
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O99- Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

KMC Manipal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Control group - no exposure of aspirin, healthy low risk pregnancy Study group - Pregnancy on aspirin 75-150mg started for primary prevention of placental dysfunction disorders

Exclusion criteria

Exclusion criteria: Structural and functional cardiac abnormality in the fetus, multiple pregnancy, unsuitable echocardiographic window

Design outcomes

Primary

MeasureTime frame
In the fetal echo Acceleration time At & Ejection time Et and At and Et ratio is used to measure pulmonary vascular maturity and Pulsatility Index and Systolic Diastolic velocities in Ductus arteriosus and Mean Pulmonary Arterial Pressure is estimated using Dabestani equation specially on right side of heart In the neonatal echo Similar data from neonatal heart and pulmonary circulation In addition to neonatal echocardiography parameters features of abnormal Transitional hemodynamics in neonate like Persistent pulmonary hypertension or ARDS or TTNB or respiratory distress or need of support or persistent cardiac shunts will be assessed Timepoint: ECHO will be done at 3 points of pregnancy & 1 in neonatal period 18 to 22 weeks routine anomaly and echo Just before stopping aspirin routine growth scan between 34 to 36 weeks 1 week before delivery routine growth scan or AFI before delivery and During routine ECHO in neonatal period—

Secondary

MeasureTime frame
In addition to neonatal echocardiography parameters features of abnormal Transitional hemodynamics in neonate like Persistent pulmonary hypertension or ARDS or TTNB or respiratory distress or need of support or persistent cardiac shunts will be assessedTimepoint: During routine ECHO in neonatal period—

Countries

India

Contacts

Public ContactDr Akhila Vasudeva

Kasturba Medical college, Manipal

akhila.vasudeva@manipal.edu9591614792

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026