To examine the effect of single oral dose of ketorolac, dexamethasone, tramadol hydrochloride on frequency and severity of pain following root canal treatment

Comparative Evaluation of the Effect of Oral Premedication with a Single Dose of Ketorolac, Dexamethasone and Tramadol Hydrochloride on the Incidence and Intensity of Post Operative Endodontic Pain: A Double Blinded Randomized Controlled Clinical Trial - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/08/056259

Enrollment

120

Registered

2023-08-08

Start date

Unknown

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: K029- Dental caries, unspecified

Interventions

Intervention1: Ketorolac, Dexamethasone and tramadol hydrochloride: Ketorolac, Dexamethasone and tramadol hydrochloride will be given in three groups to evaluate intensity and incidence of post operat

Eligibility

Inclusion criteria

Inclusion criteria: 1-Mature permanent mandibular posteriors with symptomatic irreversible pulpitis. 2-Teeth having sufficient tooth structure for adequate isolation. 3-No history of previous endodontic therapy. 4-No history of trauma to the involved tooth.

Exclusion criteria

Exclusion criteria: • Patients who have a positive history of analgesic intake within past 3 days. • Patients with periapical lesion. • Patients who have a positive history of antibiotics intake in the last month. • Periodontally compromised teeth. • Patients with known history of allergy to the drugs in study. • Diabetic, immunocompromised patients, pregnant, lactating females. • Calcified roots.

Design outcomes

Primary

Measure	Time frame
Incidence & intensity of post endodontic pain.Timepoint: 4 hours,8 hours,12hours,24 hours, 48 hours	—

Secondary

Measure	Time frame
Need & amount of rescue medication for the control of post operative painTimepoint: 4 hours,8 hours,12hours,24 hours, 48 hours	—

Countries

India

Contacts

Public ContactDr Mamta Singla

SGT DENTAL COLLEGE HOSPITAL AND RESEARCH INSTITUTE,SGT UNIVERSITY

mamta.singla@sgtuniversity.org9891381349

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026