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Comparison of two different anesthetic agents on its influence on changing hemodyanamic and doppler parameters of mitral valve diseased patients posted for valve replacement

Comparison between intravenous and inhalational anaesthetic induction agents on echocardiographic parameters of mitral stenosis patients undergoing mitral valve replacement surgery - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/08/056224
Enrollment
80
Registered
2023-08-07
Start date
Unknown
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Trans esophageal echocardiography: After anesthesia induction all patients are evaluated with trans esophageal echocardiography for mitral valve parameters. And after 3mins of induction

Sponsors

Nil
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: .1)Patients with mitral stenosis undergoing elective mitral valve replacement under cardiopulmonary bypass. 2) Age >18 and < 70years

Exclusion criteria

Exclusion criteria: 1. Patients not willing to participate in study 2. More than mild mitral regurgitation. 3. Patients with associated aortic, pulmonary and tricuspid valve disease 4. Patients with associated coronary artery disease, severe PAH. 5. Redo-surgeries 6. Emergency surgeries 7. Preoperative inotropic supports. 8. Preoperative intra-aortic balloon pump (IABP) 9. sub-optimal pre-induction and post-induction transthoracic echo images 10. Patients having post balloon mitral valvotomy atrial septal defect or any significant pathology that would affect hemodynamic parameters and echocardiographic profile.

Design outcomes

Primary

MeasureTime frame
To compare the effects of sevoflurane and Propofol induction on the following echocardiographic parameters in MS patients undergoing MVR 1. Mitral valve area (planimetry & continuity equation) 2. Peak velocity 3. Peak and mean gradient 4. Pressure half time (PHT) 5. Deceleration Time (DT) 6. Pulmonary artery systolic pressureTimepoint: 0 and 3 minutes of anesthesia

Secondary

MeasureTime frame
1. To compare the following hemodynamic parameters with Propofol & sevoflurane induction a). Mean arterial pressure(MAP) b). Cardiac output (CO) c). Heart rate ( HR) 2. To compare the Left ventricular & right ventricular function with Propofol & sevoflurane inductionTimepoint: 0 & 3 minutes of anesthesia

Countries

India

Contacts

Public ContactMohammed Jaffer Sherif

Sree chitra tirunal institute of medical science

drsherifmd19@gmail.com7838169279

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026