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Effect of a drug "dexmedetomidine" to prevent rise in blood pressure on general anesthesia

Effect of intranasal dexmedetomidine on laryngoscopic pressor response and intraoperative hemodynamic changes under general anesthesia: A double blinded randomized placebo controlled trial. - Nil

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/08/056218
Enrollment
80
Registered
2023-08-07
Start date
Unknown
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intranasal dexmedetomidine: Intranasal Dexmedetomidine will be given 0.1mcg/kg 30 mins before elective surgery Control Intervention1: Intranasal Normal saline: Intranasal Normal saline

Sponsors

Pondicherry institute of medical science
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients belongs to 18 to 60 years of age 2. ASA I, ASA II (American Society of Anesthesiologist classification) 3. Patients undergoing endotracheal intubation in elective surgery under General anesthesia 4. Duration of surgery lasting less than 3 hours

Exclusion criteria

Exclusion criteria: 1. Patients undergoing Emergency surgeries 2. Anticipated difficult airway 3. Reduced cardiopulmonary reserve 4. Patient on beta blockers 5. Previous nasal surgery 6. Laparoscopic surgery 7. Laryngoscopic time exceeding 45 seconds 8. Laryngoscopy attempts more than 2 times

Design outcomes

Primary

MeasureTime frame
Heart rate, Blood Pressure & Oxygen saturation Timepoint: A baseline heart rate, blood pressure & oxygen saturation will be measured before administration of the study drug, then at the time of administration and 10 mins once until the time of scheduled intubation. â?ª Post intubation vitals are measured at 1,2,3,4,5 & every 10 minutes until end of surgery.

Secondary

MeasureTime frame
Ramsay sedation score visual analog scoreTimepoint: 4 hrs in postoperative period

Countries

India

Contacts

Public ContactArun kumar A N

Pondicherry institute of medical science

ramyavel1988@gmail.com9487630425

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026