Health Condition 1: M009- Pyogenic arthritis, unspecified
Conditions
Interventions
Intervention1: Infected Cases: Cases suspected to have septic arthritis. These will be patients with high grade fever, elevated total leucocyte count, ESR and CRP with an ultrasound evidence of collec
Sponsors
Karthick Rangasamy
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria for Disease cases: 1) Children up to 17 years of age presented with suspected septic joint (High-grade fever, joint line tenderness, limited restriction of joint movements with joint effusion, difficulty in ambulation). 2) All medium and large joints like hip, knee, ankle, shoulder, elbow, and wrist will be included. (If there are multiple joint involvements, the joint which is more symptomatic and has more effusion will be used for sample collection) Inclusion criteria for Disease controls: 1) Children up to 16 years of age presented with multiple joint pain and effusion. (Morning stiffness, associated small joint involvement in hand and foot, associated with other system involvement like skin rash, generalized lymph adenopathy or Hepatosplenomegaly) Inclusion criteria for Healthy controls: Children up to 17 years of age undergo a procedure that is not related to infection or intraarticular pathologies. The children who sustained trauma will be of control, but joint aspiration will be done from the contralateral normal joint.
Exclusion criteria
Exclusion criteria: Exclusion criteria for cases: 1) Parents of the children not willing to give consent/participate. 2) Age >= 18 years. 3) Children sustained any major trauma around the joint in the past 2 months (other joint sites of the same children may be included) or any tumour around the joint. Exclusion criteria for both disease and healthy controls: 1) History of recent infection in the past 4 months. 2) Exposed to antibiotics in the past 10 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sensitivity & specificity of various synovial fluid markers like alpha- defensin, presepsin, neutrophil elastase, and C reactive protein (CRP) for diagnosing joint infection (septic arthritis)Timepoint: the levels of the aforementioned markers in the synovial fluid will be measured within 24 hours of sample collection | — |
Secondary
| Measure | Time frame |
|---|---|
| sensitivity & specificity of various synovial fluid markers like presepsin, neutrophil elastase, & C reactive protein (CRP) for diagnosing joint infection (septic arthritis)Timepoint: 2 years | — |
Countries
India
Contacts
Public ContactKarthick Rangasamy
Postgraduate Institute of Medical Education and Research
Outcome results
None listed