Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Opioid Free Anaesthesia: Each patient will receive Ketamine 0.5 mg/kg at the time of induction of
anaesthesia. Dexmedetomidine infusion will be prepared as 1μg/ml
after creation of
pneumoperitoneum Dexmedetomidine infusion at the rate of 0.5ml/kg/hr (0.5μg/kg/hr) will be
administered. Infusion will be stopped upon resection of the hall bladder.
Single time inf
Sponsors
University College of Medical Sciences and Guru Tegh Bahadur Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patients giving consent for the study and belonging to ASA grade I or II, scheduled for elective laparoscopic cholecystectomy under general anaesthesia.
Exclusion criteria
Exclusion criteria: 1. Patients with known cardiovascular, pulmonary, psychological or neurological diseases 2. Patients who have signs and symptoms of raised intracranial tension 3. Patients with known allergies to the study drugs 4. Obese patients (BMI > 30kg/m2)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of CRP values at 24 hours post induction in the two groupsTimepoint: 24 hours post induction | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare in the two groups: Values at 6hrs post induction of various biochemical markers such as i) CRP ii) IL-6 iii) ESR iv) S. Cortisol v) S. Albumin vi) Blood Glucose Post-operative recovery using Modified Aldrete score Post-operative pain using Numeric Rating Scale (NRS) Total dose of rescue analgesia required in 24 hoursTimepoint: 6 & 24 hours post induction | — |
Countries
India
Contacts
Public ContactDr Shubhang Singh
University College of Medical Sciences and Guru Tegh Bahadur Hospital
Outcome results
None listed