To compare the effect of IV esmolol and IV lidocaine on changes in hemodynamic parameters during extubation in elective surgeries under general anesthesia.

Comparison of effect of intravenous esmolol and preservative free lidocaine in attenuation of hemodynamic response to extubation in elective surgeries under general anesthesia - a one year hospital based single blinded Randomized Clinical Trial. - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/08/056120

Enrollment

Registered

2023-08-04

Start date

Unknown

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Esmolol: Patients will be administered 0.5 mg/kg of IV esmolol .Hemodynamic variables such as heart rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arteria

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA grade I and II 2. Patients undergoing elective surgeries under general anesthesia

Exclusion criteria

Exclusion criteria: 1. Patients with ASA grade III or more 2. Patients on beta blockers 3. Patients with allergy to study drug

Design outcomes

Primary

Measure	Time frame
To compare the effect of IV esmolol & IV lidocaine on hemodynamic variables heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial presuure (MAP) and saturation (SpO2) during extubationTimepoint: Baseline (before administration of reversal agent), post administration of reversal agent (TR), post administration of study drug (T0- after 1 minute of administering reversal agent), for every minute for the first 5 minutes post administration of study drug (T1 to T5), 7 minutes after administering study drug (T7) and finally at 10 minutes (T10). Time of extubation will also be noted.	—

Measure

Time frame

To compare the effect of IV esmolol & IV lidocaine on hemodynamic variables heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial presuure (MAP) and saturation (SpO2) during extubationTimepoint: Baseline (before administration of reversal agent), post administration of reversal agent (TR), post administration of study drug (T0- after 1 minute of administering reversal agent), for every minute for the first 5 minutes post administration of study drug (T1 to T5), 7 minutes after administering study drug (T7) and finally at 10 minutes (T10). Time of extubation will also be noted.

—

Secondary

Measure	Time frame
To study the side effect of study drugs if anyTimepoint: 1st 6 hours post surgery	—

Countries

India

Contacts

Public ContactDr Vandana Gogate

Jawaharlal Nehru Medical College, Belagavi

vandanagogate@gmail.com09019693125

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026