Health Condition 1: C538- Malignant neoplasm of overlappingsites of cervix uteri
Conditions
Interventions
Intervention1: Hypofractionated external beam radiotherapy to whole pelvis followed by brachytherapy: Whole pelvic hypo fractionated intensity modulated radiotherapy 40Gy in 16 fractions (2.5 Gray pe
Sponsors
Dr Ram Manohar Lohia Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Histologically proven squamous carcinoma of the uterine cervix of FIGO stage IB2-IIIC1(FIGO-2018) Patient being treated definitively with radiotherapy with or without concurrent chemotherapy. Patient willing to sign the informed consent Karnofsky Performance Status > 70 Normal complete blood counts, kidney and liver function tests No prior chemotherapy or radiotherapy and surgery
Exclusion criteria
Exclusion criteria: Stage other than IB2-IIIC1(FIGO2018) Patients who have received neoadjuvant chemotherapy. Any histopathology other than squamous cell carcinoma Synchronous or metachronous malignancy Pregnant or lactating women Uncontrolled concurrent illness like diabetes mellitus and hypertension
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the acute toxicity in patients of locally advanced cervical carcinoma treated with hypo fractionated intensity modulated radiotherapy followed by high dose rate brachytherapyTimepoint: Weekly during treatment, monthly for the first 3 months, then 2 monthly for the next 6 months & then 3 monthly until 2 year after treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the late toxicity & early clinical outcome in terms of loco-regional control at six months for this regimen Timepoint: 2 years from the completion of treatment | — |
Countries
India
Contacts
Public ContactDr Siddharth Burman
Dr Ram Manohar Lohia Institute of Medical Sciences
Outcome results
None listed