A clinical trial to compare two different drug schedules used for prevention of post-operative nausea and vomiting in patients undergoing total abdominal hysterectomy

To study efficacy of Dexamethasone and Palonosetron versus Promethazine and Palonosetron as prophylaxis of post-operative nausea and vomiting in patients undergoing abdominal hysterectomy under regional anaesthesia: A randomized single blind study - Nil

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/08/056041

Enrollment

160

Registered

2023-08-02

Start date

Unknown

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N998- Other intraoperative and postprocedural complications and disorders of genitourinary system Health Condition 2: N998- Other intraoperative and postprocedural complications and disorders of genitourinary system

Interventions

Intervention1: Dexamethasone and Palonosetron: Dexamethasone 4mg intravenous at the time of induction and 0.075mg Palonosetron intravenous at time of wound closure Control Intervention1: Promethazine

Eligibility

Inclusion criteria

Inclusion criteria: 1. Duration of surgery exceeding 1 hour 2. BMI 3. ASA physical status grade I and II. 4. Nonsmoker.

Exclusion criteria

Exclusion criteria: 1. Patients with gastrointestinal disease. 2. History of motion sickness. 3. Previous history of PONV. 4. Pregnancy or menstruation. 5. Those who had taken anti-emetics within 24 hours before operation. 6. Diabetics. 7. Patients with full stomach. 8. Smokers. 9. History of opioids use.

Design outcomes

Primary

Measure	Time frame
PONV incidence in both the groups.Timepoint: 48 hours	—

Secondary

Measure	Time frame
1. Serial blood sugar levels 2. Total analgesic requirement in 24 hrs 3. Side effects like headache, dizziness, diarrhea, hypotension, bradycardia if any.Timepoint: 48 hours	—

Countries

India

Contacts

Public ContactPrashant Dhatwalia

Indira Gandhi Medical College, Shimla, HP

pathaniajyoti7@gmail.com9418120659

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026