Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: IV IgM enriched Immunoglobin Mixture: 5 ml/kg body weight daily on three consecutive days. Infusion rate will be: 0.4 ml/kg/hour on day 7,8 and 9.
Control Intervention1: fluids like rin
Sponsors
all india institute of medical sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients with >20% -60% TBSA thermal flame burn area with >18 years and 2.Septic shock markers: serum lactate >4 mmol/L and arterial pressure of 3.Persistence of septic shock with =2 organ dysfunctions after initial resuscitation treatment
Exclusion criteria
Exclusion criteria: 1.Refusal to consent. 2.Patients with associated incurable metastatic malignant disease or unstable hematological malignancies, diabetics, cardiac diseases. 3.Patient is a known case of Hypersensitivity to human immunoglobulin, such as may occur in pathological immunoglobulin-G or immunoglobulin-A deficiencies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the efficacy of IV IgM enriched Immunoglobin Mixture in reducing the mortality of patients with burn sepsis within 30 days.Timepoint: 30 days. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.To determine the effect of IV IgM enriched Immunoglobin Mixture in reducing the Duration of stay in the ICU & hospital stay. 2.To determine the effect of IV IgM enriched Immunoglobin Mixture in Changing the MOF (multiple organ failure) scores 3.To determine the effect of IV IgM enriched Immunoglobin Mixture on the requirement of catecholamine therapy 4.To determine the effect of IV IgM enriched Immunoglobin Mixture on the duration of artificial ventilation Timepoint: 30 days | — |
Countries
India
Contacts
Public ContactShailendra Kumar
all india institute of medical sciences, New Delhi
Outcome results
None listed