To study the effect of injection magnesium sulphate on responses to heart rate and blood pressure during intubation in surgeries of ear, nose and throat

Evaluation of intravenous magnesium sulphate on haemodynamic responses to laryngoscopy and tracheal intubation in surgeries of ear, nose and throat - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/08/055967

Enrollment

Registered

2023-08-01

Start date

Unknown

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H758- Other specified disorders of middle ear and mastoid in diseases classified elsewhere

Interventions

Intervention1: Intravenous magnesium sulphate: Magnesium sulphate (MgSO4) inhibits catecholamine release from adrenal glands, thus reducing the levels of serum epinephrine, causes a decrease in the at

Eligibility

Inclusion criteria

Inclusion criteria: Weight between 40-65 kg, either gender , ASA physical status I and II, patients undergoing elective ENT surgery.

Exclusion criteria

Exclusion criteria: Patient refusal , emergency surgery. History of cardiovascular , pulmonary, renal , hepatic , endocrinal or neurological disease. Preoperative hypotension , patients on antipsychotics. Patient on digitalis , calcium channel blockers and alpha & beta agonist or antagonist . Sinus bradycardia, heart blocks, conduction defects. Obesity, pregnancy , lactation, anticipated difficult airway, allergy to study drugs. Any change needed in the technique of anesthesia or duration of laryngoscopy for >30 seconds.

Design outcomes

Primary

Measure	Time frame
Magnesium sulphate is effective in suppressing the haemodynamic responses to laryngoscopy & tracheal intubation in surgeries of ear, nose & throat.Timepoint: Until 5 minutes after laryngoscopy	—

Secondary

Measure	Time frame
To observe the incidence & severity of adverse effects of intravenous magnesium sulphate, if any.Timepoint: Until 5 minutes after laryngoscopy	—

Countries

India

Contacts

Public ContactUrvi Arun Sawant

Datta Meghe Institute of Higher Education and Research

jayashree_sen@rediffmail.com9813061192

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026