Health Condition 1: C910- Acute lymphoblastic leukemia [ALL] Health Condition 2: N040- Nephrotic syndrome with minor glomerular abnormality Health Condition 3: M084- Pauciarticular juvenile rheumatoidarthritis Health Condition 4: M321- Systemic lupus erythematosus withorgan or system involvement
Conditions
Interventions
Control Intervention1: NIL: NIL
Sponsors
Department of Health Research
Eligibility
Inclusion criteria
Inclusion criteria: Children with the following three diseases, who are either newly diagnosed or on follow up will be recruited: 1. Rheumatic Disease (RD): Children between 1 month to 18 years with diagnosis of Juvenile Idiopathic Arthritis (JIA), Systemic Lupus Erythematosus (SLE). (13)(14). 2. Nephrotic syndrome (NS): Children between 1 month to 18 years with diagnosis of Nephrotic syndrome (first episode, relapse, steroid dependent, steroid resistant). (15). 3. Acute Lymphoblastic leukemia (ALL): Children between 1 month to 18 years with diagnosis of Acute Lymphoblastic Leukemia (16). Newly diagnosed cases of all three diseases will be included within 14 days of diagnosis. The follow up cases will be included if they have received at least 3 months of daily or alternate day steroid therapy, more than physiological replacement dose ( >2 mg/m2/day prednisolone equivalent) in last 6 months.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Incidence of VF & GIO among children exposed to steroidsTimepoint: At enrolment, 6 and 12 months after enrollment | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To study the risk factors for development of VF & osteoporosis 2. To study the progression of VF and osteoporosis among those with VF at the time of diagnosis 3. Correlation of lumbar spine BMD with vertebral fragility fracture Timepoint: At recruitement, 6 months & 1 year after recruitement | — |
Countries
India
Contacts
Public ContactDr Koushik H
Kasturba Medical College, Manipal
Outcome results
None listed