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A clinical trial to study the effects of dexmedetomidine on recovery from general anesthesia through two different routes, one in the airway and the other through blood and compare them with each other in laparoscopic surgery.

Comparison of effects of intratracheal with intravenous dexmedetomidine on recovery from general anaesthesia after laparoscopic surgeries: A randomized controlled double blind study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/08/055941
Enrollment
114
Registered
2023-08-01
Start date
Unknown
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: INTRATRACHEAL DEXMEDETOMIDINE: Dexmedetomidine 0.5mcg/kg(diluted and mixed in 1ml saline) will be administered into trachea using an epidural catheter 30 minutes before end of surgery t

Sponsors

KING GEORGES MEDICAL UNIVERSITY
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Body weight 40-80kg American Society of Anesthesiologists class1, 2 undergoing laparoscopic surgery of duration upto 3 hours

Exclusion criteria

Exclusion criteria: 1. Unwilling patients 2. Respiratory diseases 3. Cardiac diseases with might represent risk factors of potential complications of dexmedetomidine 4. Long term use of sedative drugs, benzodiazepines, barbiturates and sedative hypnotics 5. Patients transferred to open surgery during operation.

Design outcomes

Primary

MeasureTime frame
Comparison of coughing severityTimepoint: During recovery period from time of awareness to 5 minutes after extubation—

Secondary

MeasureTime frame
Postoperative visual analogue scaleTimepoint: 5 minutes after extubation 15 minutes after extubation 30 minutes after extubation;Awareness timeTimepoint: calculated from end of surgery to the time when patient follows verbal command;Extubation timeTimepoint: From end of surgery till patient is extubated;Mean Arterial pressure, Heart rateTimepoint: 5 minutes before anesthesia Immediately after administration of Dex 10 minutes after administration of Dex At the end of surgery At the point of awareness At the point of extubation 2 minutes after extubation 5 minutes after extubation 15 minutes after extubation 30 minutes after extubation ;Postoperative nausea vomitingTimepoint: Till 30 minutes after surgery;Postoperative recovery score ( Steward recovery score)Timepoint: 5 minutes after extubation 15 minutes after extubation 30 minutes after extubation—

Countries

India

Contacts

Public ContactESHA BATRA

KING GEORGES MEDICAL UNIVERSITY

dineshkgmu@gmail.com7905492858

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026