Study of change of blood pressure and heart rate response to placement of tube into windpipe by an instrument to see voice box inside throat by giving tablet Ivabradine (heart rate lowering medication) and tablet Clonidine (decreases heart rate)

â??Study of attenuation of the hemodynamic response to laryngoscopy and endotracheal intubation comparing oral Ivabradine and oral Clonidine - A Randomized control study â?? - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/08/055936

Enrollment

Registered

2023-08-01

Start date

Unknown

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Nil: Nil Intervention2: Ivabradine: Cardio stable drug therapy Intervention3: Atropine: During bradycardia within 1 minute to 5 mins Control Intervention1: Clonidine: Cardio stable dru

Eligibility

Inclusion criteria

Inclusion criteria: Patient should be of age 18-60 yrs. Patient to get fit under ASA PS I and II Patient should undergo Elective non cardiac surgery under General Anesthesia

Exclusion criteria

Exclusion criteria: Patient who refused to give consent for study. Patient with known hypersensitivity to these study drugs. Baseline Heart rate less than 60 Baseline systolic Bp less than 100. Those with ECG abnormalities. Patients with history of chest pain/palpitations/syncope, Patients with history of any visual disturbances, with Sick sinus syndrome. Patients already on calcium channel blockers, azole antifungals, antiretroviral drugs and macrolide antibiotics, with hepatic impairment or renal dysfunction, pregnant and breastfeeding females and 9. Patients in whom intubation is thought to be difficult (time taken to intubate >

Design outcomes

Primary

Measure	Time frame
To the best of literature . There is no study evaluating the hemodynamic attenuation of laryngoscope and endotracheal intubation comparing oral ivabradine & oral clonidine & with the previous studies & previous records .however studies have done between clonidine vs gabapentin & ivabradine alone. Timepoint: Laryngoscopic response till 5 minutes	—

Secondary

Measure	Time frame
1. To the study the effect of these drugs on hemodynamic during intra operative & post operative Period . 2. To study about the side effects & complications such as visual disturbances , arrhythmias, etc , if any due to the study drugs. Timepoint: At baseline ,1 hr , 2hrs , 3hrs , one week	—

Countries

India

Contacts

Public ContactRANJAN R V

Sri Manakula Vinayagar Medical College and Hospital

prasanth2040@gmail.com9597797694

Outcome results