observing the intravenous drugs ketamine, dexmeditomidine and combination of ketamine of dexmeditomidine in the mitigation of agitation following general anaesthesia in patients undergoing nasal surgeries

Comparison of ketamine, dexmedetomidine, ketodex in prevention of emergence agitation in adults undergoing nasal surgery - NIL

Status

Recruiting

Phases

Phase 4

Study type

Observational

Source

CTRI

Registry ID

CTRI/2023/07/055886

Enrollment

Registered

2023-07-31

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J30-J39- Other diseases of upper respiratory tract

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: Patients of either sex scheduled for elective nasal surgeries under general anaesthesia -American society of Anesthesiologists physical status I,II

Exclusion criteria

Exclusion criteria: Patients with altered mental status Patients on psychoactive/analgesics/ Beta agonist drugs Pregnant women Patient with known allergy or hypersensitivity to the drugs used in the study Patients with anticipated difficult airway

Design outcomes

Primary

Measure	Time frame
To compare the level of emergence agitation in patients receiving ketamine, dexmedetomidine and ketodex atrecovery from general anaesthesia & admission to post anaesthesia care unit, Hemodynamic parameters, post operative nausea vomiting, pain score Timepoint: Level of agitation assessed by Riker Sedation Agitation scale, At recovery & at admission to PACU. hemodynamic parameters, postoperative nausea vomiting and pain scores every 15 minutes till 30 minutes, followed by every 30 minutes for 2 hours at post operative anaesthesia care unit	—

Measure

Time frame

To compare the level of emergence agitation in patients receiving ketamine, dexmedetomidine and ketodex atrecovery from general anaesthesia & admission to post anaesthesia care unit, Hemodynamic parameters, post operative nausea vomiting, pain score Timepoint: Level of agitation assessed by Riker Sedation Agitation scale, At recovery & at admission to PACU. hemodynamic parameters, postoperative nausea vomiting and pain scores every 15 minutes till 30 minutes, followed by every 30 minutes for 2 hours at post operative anaesthesia care unit

—

Secondary

Measure	Time frame
Discharge time in minutesTimepoint: The time from arrival to post-anaesthesia care unite (PACU) to discharge to the ward according to modified Aldrete score;Extubation timeTimepoint: Time from discontinuing sevoflurane to extubation.;Recovery timeTimepoint: Time in minutes from when sevoflurane is discontinued,to response to first verbal command;Level of painTimepoint: Will be assessed by Numeric pain rating scale at admission to postoperative anaesthesia care unit & at discharge from postoperative anaesthesia care unit.;Hemodynamic parametersTimepoint: every 15 minutes till 30 minutes, followed by every 30 minutes for 2 hours at post operative anaesthesia care unit ;Post operative nausea vomiting:Timepoint: assessed by 4 Point Post operative nausea & vomiting scale at admission to post operative care unit and at discharge from post operative care unit	—

Measure

Time frame

Discharge time in minutesTimepoint: The time from arrival to post-anaesthesia care unite (PACU) to discharge to the ward according to modified Aldrete score;Extubation timeTimepoint: Time from discontinuing sevoflurane to extubation.;Recovery timeTimepoint: Time in minutes from when sevoflurane is discontinued,to response to first verbal command;Level of painTimepoint: Will be assessed by Numeric pain rating scale at admission to postoperative anaesthesia care unit & at discharge from postoperative anaesthesia care unit.;Hemodynamic parametersTimepoint: every 15 minutes till 30 minutes, followed by every 30 minutes for 2 hours at post operative anaesthesia care unit ;Post operative nausea vomiting:Timepoint: assessed by 4 Point Post operative nausea & vomiting scale at admission to post operative care unit and at discharge from post operative care unit

—

Countries

India

Contacts

Public ContactRama Rani K

Kasturba Medical College,Manipal

rama.rani@manipal.edu9902938044

Outcome results