Comparing Sugammadex and Neostigmine for faster and smoother recovery from anaesthesia in brain surgery patients.

A comparison of rapidity and recovery of neuromuscular blockade of Sugammadex versus Neostigmine in adults undergoing elective craniotomies: A prospective randomized double blind single centre study. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/07/055876

Enrollment

130

Registered

2023-07-31

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G939- Disorder of brain, unspecified Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Sugammadex or Neostigmine Methyl sulphate as reversal agents.: Either Sugammadex or Neostigmine will be injected for reversal of neuromuscular blockade of Vecuronium Bromide when train

Eligibility

Inclusion criteria

Inclusion criteria: Elective craniotomies ASA I & II

Exclusion criteria

Exclusion criteria: Awake craniotomies Posterior fossa craniotomies requiring neuro-monitoring Paediatric age group ASA III-IV Allergies to study drug Chronic kidney disease Chronic liver disease Neuro-degenerative, neuromuscular disorders Pregnancy

Design outcomes

Primary

Measure	Time frame
Comparison of rapidity of reversal from neuromuscular blockade of Sugammadex versus Neostigmine.Timepoint: At extubation	—

Secondary

Measure	Time frame
Comparing haemodynamic events & complications of Sugammadex versus Neostigmine.Timepoint: Until 1 hour from the administration of reversal agent.;Comparison of recovery from neuromuscular blockade of Sugammadex versus Neostigmine.Timepoint: Time taken to achieve modified Aldrete score of 9/10 after extubation.	—

Countries

India

Contacts

Public ContactDr Joslita Rebello

P D Hinduja hospital and medical research centre

monteiro04@gmail.com919821158949

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026